Protein Alignment Grd and Gabrp

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_666129.1
• Gene: Gabrp / 216643
• MGIID: 2387597
• Length: 440
• Species: Mus musculus
• Alignment Length: 595
• Identity: 148/595 - (24%)
• Similarity: 247/595 - (41%)
• Gaps: 190/595 - (31%)

  Fly    98 SWLTQ----SNNHANI----SELL-----DNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISE 149
            |.|||    ..|..|:    |:.|     :||..||:..:||:|||.|..|.:.:.:.|:..|||
Mouse    13 SLLTQRTCIQGNQVNVEVSRSDKLSLPGFENLTAGYNKFLRPNFGGDPVRIALTLDIASISSISE 77

  Fly   150 VDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVR 214
            .:|.|:...|.||.|.|.||.||| ..:..|...::..:|.||||....|:|:||.:|..|:.:|
Mouse    78 SNMDYTATIYLRQRWTDPRLVFEG-NKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIR 141

  Fly   215 IYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMK 279
            ::.||.|||:.|:|....|.|:|:.:|||.|.|.|:..|:||..:||.:.|.:....|...|:::
Mouse   142 LFSNGTVLYALRITTTVTCNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLRGNDSVRGLENLR 206

  Fly   280 LSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLD 344
            |:|:.:                                               .|:..
Mouse   207 LAQYTI-----------------------------------------------QQYFT------- 217

  Fly   345 KGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLS 409
                                  .:|:.......|:.|::.|.|:|::..|:::.|.|...|||||
Mouse   218 ----------------------LVTVSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLS 260

  Fly   410 WVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVS-YPTALDFFVFLSFGFIFATILQFA 473
            |||||::.::...|..:|:||||:||.|.:.:||.||..: :..|:|.::.:.|.|:|..:|::|
Mouse   261 WVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYA 325

  Fly   474 VVHYYTKYGSGECYFIIEELDSESGESETEPLTSDFRG----STESKIYEVIPLSMCAISMPPPP 534
            |.||                      |..:.:....||    |.|..|..:|..|:.:.
Mouse   326 VAHY----------------------SSLQQMAVKDRGPAKDSEEVNITNIINSSISSF------ 362

  Fly   535 TRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAA 599
                          .|:....|:::.|                ::.:.....::|::
Mouse   363 --------------KRKISFASIEISG----------------DNVNYSDLTMKASD-------- 389

  Fly   600 AAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSV---SKIDRASRIVFPLLFIL 661
                                :..:..||::      .|...|.::   |.:||.|:::|||:|:|
Mouse   390 --------------------KFKFVFREKI------SRIIDYFTIQNPSNVDRYSKLLFPLIFML 428

  Fly   662 INVFYWYGYL 671
            .|||||..|:
Mouse   429 ANVFYWAYYM 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	140/571 (25%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	57/167 (34%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)
Gabrp	NP_666129.1	LIC	43..437	CDD:455710	139/562 (25%)
		LGIC_ECD	60..241	CDD:475126	63/257 (25%)