Protein Alignment Grd and Gabrr3

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_620252.1
• Gene: Gabrr3 / 192258
• RGDID: 621564
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 557
• Identity: 149/557 - (26%)
• Similarity: 237/557 - (42%)
• Gaps: 158/557 - (28%)

  Fly   117 LRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQD-TLAL 180
            :..:|.|.||.|||.|..:.:|:.|.|:..||||:|.::|..|.|..|.|:||:|....: ::..
  Rat    64 IEDHDFSTRPGFGGSPVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPSTTNKSMTF 128

  Fly   181 SVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQ 245
            ...::.:||.||.:|.:.|:|::|..|..|..:|::.:|.||:|.|:|:.|.|.|:.:.||:|.|
  Rat   129 DRRLIQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQ 193

  Fly   246 KCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPF 310
            .|.|:..|:.|...|::..|......:...|.:.||||.:.:..|
  Rat   194 NCSLELESYAYNEEDLMLYWKHGNKSLNTEEHISLSQFFIEEFSA-------------------- 238

  Fly   311 NNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHP 375
                                       .:||     ||          .|:||.
  Rat   239 ---------------------------SSGL-----AF----------YSSTGW----------- 250

  Fly   376 SEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLE 440
              |..|.:||.|:||:..|::|.|.|..|:|:|||||||::|.|...||||||||||||:.:...
  Rat   251 --YYRLFINFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTG 313

  Fly   441 ARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEPL 505
            ....:|:|||..|:|.::::|..|:|.:::::|.|:|.|         .:||....:
  Rat   314 VSASMPQVSYVKAVDVYMWVSSLFVFLSVIEYAAVNYLT---------TVEEWKQLN-------- 361

  Fly   506 TSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRK 570
                |....|.:|.:                               ..:.:|...|.:.
  Rat   362 ----RRGKISGMYNI-------------------------------DAVQAMAFDGCYH------ 385

  Fly   571 PPRADSDEDEDDEQTQLRANE-APTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRK 634
                |.:.|.|.....|.:.| :..|....:....::|..|.|  .||               ..
  Rat   386 ----DGETDVDQTSFFLHSEEDSMRTKFTGSPCADSSQIKRKS--LGG---------------NV 429

  Fly   635 GKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYL 671
            |:...:.|.|  ||..||||||:::|:.|:|||..|:
  Rat   430 GRIILENNHV--IDTYSRIVFPVVYIIFNLFYWGIYV 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	60/209 (29%)
		LIC	111..670	CDD:273305	148/554 (27%)
		Neur_chan_memb	398..667	CDD:280999	70/269 (26%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:273305	148/554 (27%)
		LGIC_ECD	79..264	CDD:355788	66/259 (25%)
		Cys-loop	181..195	CDD:349787	6/13 (46%)
		Interaction with SQSTM1. /evidence=ECO:0000269|PubMed:12431995	344..445		27/181 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810