Protein Alignment Grd and lgc-40

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001407536.1
• Gene: lgc-40 / 188854
• WormBaseID: WBGene00020767
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 149/574 - (25%)
• Similarity: 232/574 - (40%)
• Gaps: 149/574 - (25%)

  Fly   120 YDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSM 184
            ||..||....|.|..:.:.:.:..|...|...|.|.:|.||::.|.|.|||...:...|...:::
 Worm    53 YDEYIRVHGTGVPTNVTLSMFIEGMSSFSAQTMDYHLDVYFQEEWYDHRLAHNASAPILVRDLTV 117

  Fly   185 LARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPL 249
            ...:|.||.||.|.:.:....||..|..|.:|.||||.|.:|::|.:.|.|:|..:|:|.|:|.|
 Worm   118 FKMMWHPDVYFANARSAAFQDITDDNFLVWVYPNGRVWYDARISIVSSCNMDLWKYPLDSQECAL 182

  Fly   250 KFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKD 314
            :..|:.|..:.:...|:::.                 |.||.:                  .|.|
 Worm   183 RILSYAYPMTVLRLLWSEKE-----------------DVPAID------------------RNPD 212

  Fly   315 PPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYS 379
            ...|...:           :|:| ||       :..|..|||                    |:|
 Worm   213 ITMPDMSL-----------KHIR-TG-------YCNGTYATG--------------------EWS 238

  Fly   380 MLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTD 444
            .:...|:::|.|.:.::|.|.|..|:||:||.:|||..::...||||.|||:||::......:..
 Worm   239 CMTAIFYVEREMMHHVMQTYVPTALIVVISWFNFWLEIDSAPARVSLSITTLLTISTQANAVKLA 303

  Fly   445 LPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKY----GSGECYFIIE-----------ELD 494
            ||:|||..|:|.::.....|:|..:::|.:.||....    |.|:...|::           ::|
 Worm   304 LPEVSYMKAIDVWMGSCMAFVFGVMIEFTICHYAKNLEMLRGDGQPSLIVDTALSTLFGAARDID 368

  Fly   495 SESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRH---GLWS 556
            ....:..|.......||..|    :.|.|:|    :.|...||..|...|....|...   |...
 Worm   369 DLVRKVATLNEEEGVRGDGE----QHIALNM----LNPEEPRLRSLNQNNDVTANGTRYFVGAER 425

  Fly   557 MKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPT--GGRR 619
            ||       |:|.|                            |:.::...|.|.:...|  ..||
 Worm   426 MK-------RKRSK----------------------------ASLSRLRQQVASMRHATIDVSRR 455

  Fly   620 RMSYYRREEMEARR--KGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYL 671
            ..::.|     |.|  :|:|..|     :||...|||||::|:|.||.||..||
 Worm   456 AFNWTR-----ALRNLRGRRVAQ-----RIDERCRIVFPMIFLLFNVAYWSFYL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	147/571 (26%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	46/167 (28%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
lgc-40	NP_001407536.1	LIC	31..498	CDD:455710	147/571 (26%)