Protein Alignment Grd and lgc-50

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_498637.3
• Gene: lgc-50 / 188633
• WormBaseID: WBGene00020605
• Length: 491
• Species: Caenorhabditis elegans
• Alignment Length: 620
• Identity: 151/620 - (24%)
• Similarity: 229/620 - (36%)
• Gaps: 202/620 - (32%)

  Fly   103 SNNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDK 167
            |.|..|:.:|:|.||..||..:.|:..|...|||  :.|:.:..|||:...:|:|..:.:.|.|.
 Worm    26 SRNSINLGKLIDTLLTDYDTHLLPEAEGVNVTIE--LHVQGVSGISEITGDFSLDVMYSEIWQDP 88

  Fly   168 RLAFEG---AQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTI 229
            ||:|:.   ....:.|......:||.|||...|.|.|.:|:..:.|.||.:|:||.|..:.||.:
 Worm    89 RLSFKHLNVCATNITLKSDFRKKIWTPDTCIINSKSSSIHSSPSENTFVILYENGLVWSNFRLNV 153

  Fly   230 KAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLT 294
            |..|.:||..||.|...|.:...|:.:.|.:|...|:.  .|:.:.|.::|..|||:    |..|
 Worm   154 KTPCSVNLKMFPFDSLSCEIVLESYSFNTDEVRLMWHD--VPITMMEKVELPDFDLI----GWST 212

  Fly   295 DIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSG 359
            |         .||..:.|....|  :||..|||
 Worm   213 D---------HQRLEYPNGIWDR--AKVKFTFA-------------------------------- 234

  Fly   360 STTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRV 424
                                         |..|.:|.|.|.|..|.|:.|||.|:.:..:.:.|:
 Worm   235 -----------------------------RRYGFYLFQSYFPTSLTVISSWVGFFFDVRSVSARI 270

  Fly   425 SLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFI 489
            :||::::|.:||........||:|||...||.::..|..|||.|:::.|:|
 Worm   271 TLGVSSLLALTFQFGNVLRHLPRVSYIKCLDVWMIFSVIFIFCTLVELAIV-------------- 321

  Fly   490 IEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGL 554
                                                |.:               ||..|.|:.|
 Worm   322 ------------------------------------CQL---------------NRWERERQIG- 334

  Fly   555 WSMKLLGLFDWRRR-RKPPRADSDEDED-------------DEQTQLRANEAPTTSAAAAAAQAA 605
              .|:||  .|..: ||..:.:|..||.             ....||:|....:.|.||.|...|
 Worm   335 --SKVLG--HWLNQIRKTRKKESKADEGGGGGVGGLLRKRIPVLAQLKAAATDSNSGAATAMTTA 395

  Fly   606 AQAARISPPTGGRRRMSYYRREEMEA--------------RRKG---------------KRTPQY 641
                 |.||......::.....::.|              :::|               .|....
 Worm   396 -----IQPPNTNLNSITNSDNSKLVANNFTSIEHETYAYEKKRGFSHCFQRFVYAICPPDRDWTI 455

  Fly   642 NSVSKIDRASRIVFPLLFILINVFYWYGYLSRSSR 676
            .|| ::||.|.|:|||.|::.||.||..|..:..|
 Worm   456 TSV-QVDRCSMIMFPLSFLIFNVVYWSIYFMKMDR 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	68/218 (31%)
		LIC	111..670	CDD:273305	146/604 (24%)
		Neur_chan_memb	398..667	CDD:280999	69/311 (22%)
lgc-50	NP_498637.3	LIC	34..483	CDD:273305	146/604 (24%)
		Neur_chan_LBD	34..237	CDD:280998	72/282 (26%)
		Neur_chan_memb	245..480	CDD:280999	69/310 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810