Protein Alignment Grd and lgc-54

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001343648.1
• Gene: lgc-54 / 188525
• WormBaseID: WBGene00020528
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 674
• Identity: 148/674 - (21%)
• Similarity: 242/674 - (35%)
• Gaps: 258/674 - (38%)

  Fly    79 GDTHRLG------EMGTSLSSSLPSSWLTQSNNH--------AN--ISELLDNLLRGYDNSIRPD 127
            |.|.||.      .:|.:: |:||........|:        ||  ||:|:  |.|.:|::...:
 Worm     6 GFTERLNLFTLIWGLGNAI-STLPEPQTAPIENYDWMHCDEPANDTISQLV--LRRLFDDNYNKN 67

  Fly   128 ---FGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE---GAQDTLALSVSMLA 186
               .......:.|:..::::..:||:..::::|..|.|.|.|.||.|:   .....|.|..||:.
 Worm    68 TVPLKTSATVVSVEFGIQNIAQVSEISASFTLDLLFSQIWHDPRLRFDHLTNCLQNLTLGYSMVE 132

  Fly   187 RIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKF 251
            ::|.|:..|.|.|::.:|:..|||.|:.||.||.|..:.||.:::.|.::|..|||||..|.|..
 Worm   133 KLWTPNVCFVNSKKTEIHSSPTPNIFLMIYPNGTVWVNYRLQVQSPCMVDLVLFPMDIMNCELII 197

  Fly   252 GSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPP 316
            .|:.|..:.|...|.:.:|..:||:. |||.|.|.
 Worm   198 ESYAYNAAKVKLNWREWQPVFSIAKS-KLSDFTLY------------------------------ 231

  Fly   317 RPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSML 381
                                   ||:..|.:|   ..|.|                    ::..|
 Worm   232 -----------------------GLQWTKNSF---EYAAG--------------------QWDQL 250

  Fly   382 MVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLP 446
            .|:....|..|.:::|:|.|....|.||:||||::.:|...|::||:::::.:||.......:||
 Worm   251 TVSLTFSRAYGFYILQMYIPTYSSVFLSFVSFWIDLKALPARITLGVSSLMALTFQYGNVAKNLP 315

  Fly   447 KVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSES--------GESETE 503
            :|.|..::|.::.|:..|||.|:::.|.|          ||     ||||:        .|.:.|
 Worm   316 RVGYVKSIDVYMVLTTAFIFLTMIEVAFV----------CY-----LDSENNLRRKERQAEKKKE 365

  Fly   504 PLT-------------------------SDFR----------GSTESKIYEVIPLSMCAISMPPP 533
            .:.                         ||.|          |:|..||
 Worm   366 RVAVLQRKKDRKKNNYGATTVTNANAAESDLRSNYDEPFSQNGTTSHKI---------------- 414

  Fly   534 PTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAA 598
                    |.:|:..|....|.::...||.              .|:|||.|:..|
 Worm   415 --------SISRQANNMFESLHALAQFGLL--------------TDDDDENTKWTA--------- 448

  Fly   599 AAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILIN 663
                                                          ..:|:..|..|||.|..:|
 Worm   449 ----------------------------------------------QNVDKFCRKAFPLSFCFLN 467

  Fly   664 VFYW-----YGYLSRSSRILANTP 682
            :.||     ..||:::..:...||
 Worm   468 LIYWCYYLYQNYLAKAEALAQMTP 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	131/612 (21%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	53/170 (31%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)
lgc-54	NP_001343648.1	LIC	55..474	CDD:455710	130/605 (21%)
		LGIC_ECD_GABAAR	76..258	CDD:349791	61/258 (24%)
		Cys-loop	179..193	CDD:349791	7/13 (54%)