Protein Alignment Grd and acc-3

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_508810.2
• Gene: acc-3 / 186307
• WormBaseID: WBGene00018880
• Length: 517
• Species: Caenorhabditis elegans
• Alignment Length: 580
• Identity: 135/580 - (23%)
• Similarity: 222/580 - (38%)
• Gaps: 153/580 - (26%)

  Fly   112 LLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE---G 173
            :::.||..|.:...|...|  ..:.:::.|:.:..::|:...:.||.|..:.|:|..|.:|   .
 Worm    69 IIEKLLNNYKSFRTPSESG--VIVWIEVWVQEVNSVNEITSDFDMDIYVTELWMDSALRYEHLNP 131

  Fly   174 AQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLA 238
            .:..|:|:..:|.:||||:|.|.|.|.:.:|.....|.|:.||.||.|..:.|:.:|..|.|:.:
 Worm   132 CKYNLSLNSEILDQIWKPNTVFINSKSANIHKSPFKNVFLMIYPNGTVWVNYRVQVKGPCSMDFS 196

  Fly   239 DFPMDIQKCPLKFGSFGYTTSDVIYRW-NKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAA 302
            .||||.|.|.|...||.|...:|..:| |...|...:.:::.|..|
 Worm   197 AFPMDQQSCHLTLESFSYNNQEVDMQWMNWTTPLSLLKKEIVLPDF------------------- 242

  Fly   303 PRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGT 367
                               ||:.::           |.||.:....|.
 Worm   243 -------------------VMSNYS-----------TSLKHEIYPAGV----------------- 260

  Fly   368 ITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVL 432
                      ::.|.:.|...|..|.::.|.|.|..|.:.:||:||.|..:....|..||:.::|
 Worm   261 ----------WNELTMTFVFSRRYGWYIFQAYIPTYLTIFISWISFCLGPKMIPARTMLGVNSLL 315

  Fly   433 TMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSES 497
            .:||.......:||:|||..|||.::.:...|:|.::|:.|::        |......|...::.
 Worm   316 ALTFQFGNIMRNLPRVSYVKALDVWMLVCLTFVFCSLLELAII--------GSMGARSENRQAQQ 372

  Fly   498 GESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGL 562
            .:.:.|..|...:|...|....::..|.|     |...|:    .||..|.:...   |.|..|.
 Worm   373 QKQQDEEATKHQKGRENSTCSHLMSPSSC-----PNSPRI----CRNHIPNDVPQ---SFKSYGS 425

  Fly   563 FDWRRRRK-----------PPRADSDED----EDDEQTQLRANEAPTTSAAAAAAQAAAQAARIS 612
            .|.|.|::           .|.|:..|.    :..|:||....|...:|.|:.
 Worm   426 TDPRMRKRLIIASSSTISHAPNANRSEKVLLLDGLEETQFSQVETKFSSMASI------------ 478

  Fly   613 PPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLS 672
                  :...::..||                  |||.|.|:||.||.|.|:.||..||:
 Worm   479 ------KMKKHWTTEE------------------IDRLSMIMFPGLFTLFNIIYWTYYLT 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	133/576 (23%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	48/171 (28%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)
acc-3	NP_508810.2	LIC	69..512	CDD:455710	133/576 (23%)
		LGIC_ECD_GABAAR	88..273	CDD:349791	56/260 (22%)
		Cys-loop	191..205	CDD:349791	7/13 (54%)