Protein Alignment Grd and lgc-41

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001360683.1
• Gene: lgc-41 / 183331
• WormBaseID: WBGene00008022
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 664
• Identity: 161/664 - (24%)
• Similarity: 252/664 - (37%)
• Gaps: 200/664 - (30%)

  Fly    97 SSWLTQSNNHANISELLDNLLRGYDNSIRPDFGGP--PATIEVDIMVRSMGPISEVDMTYSMDCY 159
            ||.|||.|        :.|||:  .::.||.....  |..:::.:.:.|:|.....:|::.:|.|
 Worm    23 SSPLTQPN--------IYNLLQ--QSNTRPPTANASVPLGVKLGMYLESLGNFRSSEMSFDVDLY 77

  Fly   160 FRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYS 224
            ...||.|.|||...:...|..:..:..:||.||.||.|.:|:....:|.||..:.:..:|.|.||
 Worm    78 VYMSWQDPRLAHNFSDYVLINNDEIRKQIWLPDLYFANARQASFQEVTVPNFNLFVAPDGTVAYS 142

  Fly   225 SRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCP 289
            .|.|:...|.:||..:|||.|.|.::..|:.|....|...| .::.||...|::.|.:|.:
 Worm   143 CRCTLTVACSLNLRYYPMDQQLCSIRVLSYAYIAKQVNVTW-FDKNPVRFNEEIGLPEFQI---- 202

  Fly   290 AGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDA 354
                                                        :||        ..|:..|
 Worm   203 --------------------------------------------EHV--------SNAYCNG--- 212

  Fly   355 TGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREA 419
                    .....:|..:....::|.|..|..|.|.:|..|:|.|.|..|:|::||||||::|.|
 Worm   213 --------SYQYALTENSYKSDDFSCLSGNLFLSRSIGYNLVQSYIPTGLIVMISWVSFWIDRRA 269

  Fly   420 TADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSG 484
            ...||:|..||::::|.||...|..||:|||..|:|.:......|:|..:|:||.::.|.:..
 Worm   270 VPARVTLSFTTLVSLTTLGNGLRFGLPQVSYAKAIDLWYGACMFFVFCALLEFATINSYMRKS-- 332

  Fly   485 ECYFIIEELDSESGESETEPLTS---DF--RGSTES---------KIYEVIPLSMCAISMPPPPT 535
                  |:.||.:.:.::..||.   |:  ||..||         .:.:.:....|..|
 Worm   333 ------EKFDSMAKKMQSVVLTGRTRDYLVRGIKESMRIAGGAAGNVVDALNDDWCTYS------ 385

  Fly   536 RLGMLTSRNRRP-------------------RNRRHGLWSMKLLGLFDWRRRRKPPRA------- 574
                 |...|:.                   |||..||            :..|.||.
 Worm   386 -----TENGRKSFSAMVGDIFERAGNAISPRRNRYRGL------------KTEKSPRGYGKPDTV 433

  Fly   575 ---------------DSDEDEDDEQTQLRANEA----PTTSAAAAAAQAAAQAARISPP-----T 615
                           |.|..||||   :..|.|    ...|.....|.::::..:.|..     |
 Worm   434 QDILSERIKFIDNEFDFDTKEDDE---IPGNMAMSIYDNVSCRKDEADSSSEETKFSTKPKRNGT 495

  Fly   616 GGRRRMSYYRREEMEARRKGKR----TPQYNSVS--------KIDRASRIVFPLLFILINVFYWY 668
            .|.|:..     :....:.|:.    ...|..:|        |||::.|.:||..|:|.|||||:
 Worm   496 NGTRKYI-----DKSLNQSGQNDSLIVATYFQISANHSRHALKIDKSCRYLFPAAFLLWNVFYWW 555

  Fly   669 GYLSRSSRILANTP 682
            .||     :...||
 Worm   556 YYL-----VYTKTP 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	151/636 (24%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	47/167 (28%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)
lgc-41	NP_001360683.1	LIC	41..>332	CDD:455710	96/358 (27%)
		LGIC_TM	<527..557	CDD:476813	13/29 (45%)
		TM4 helix	533..554	CDD:349850	11/20 (55%)