Protein Alignment Grd and lgc-41

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001360683.1
• Gene: lgc-41 / 183331
• WormBaseID: WBGene00008022
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 664
• Identity: 161/664 - (24%)
• Similarity: 252/664 - (37%)
• Gaps: 200/664 - (30%)

  Fly    97 SSWLTQSNNHANISELLDNLLRGYDNSIRPDFGGP--PATIEVDIMVRSMGPISEVDMTYSMDCY 159
            ||.|||.|        :.|||:  .::.||.....  |..:::.:.:.|:|.....:|::.:|.|
 Worm    23 SSPLTQPN--------IYNLLQ--QSNTRPPTANASVPLGVKLGMYLESLGNFRSSEMSFDVDLY 77

  Fly   160 FRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYS 224
            ...||.|.|||...:...|..:..:..:||.||.||.|.:|:....:|.||..:.:..:|.|.||
 Worm    78 VYMSWQDPRLAHNFSDYVLINNDEIRKQIWLPDLYFANARQASFQEVTVPNFNLFVAPDGTVAYS 142

  Fly   225 SRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCP 289
            .|.|:...|.:||..:|||.|.|.::..|:.|....|...| .::.||...|::.|.:|.:
 Worm   143 CRCTLTVACSLNLRYYPMDQQLCSIRVLSYAYIAKQVNVTW-FDKNPVRFNEEIGLPEFQI---- 202

  Fly   290 AGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDA 354
                                                        :||        ..|:..|
 Worm   203 --------------------------------------------EHV--------SNAYCNG--- 212

  Fly   355 TGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREA 419
                    .....:|..:....::|.|..|..|.|.:|..|:|.|.|..|:|::||||||::|.|
 Worm   213 --------SYQYALTENSYKSDDFSCLSGNLFLSRSIGYNLVQSYIPTGLIVMISWVSFWIDRRA 269

  Fly   420 TADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSG 484
            ...||:|..||::::|.||...|..||:|||..|:|.:......|:|..:|:||.::.|.:..
 Worm   270 VPARVTLSFTTLVSLTTLGNGLRFGLPQVSYAKAIDLWYGACMFFVFCALLEFATINSYMRKS-- 332

  Fly   485 ECYFIIEELDSESGESETEPLTS---DF--RGSTES---------KIYEVIPLSMCAISMPPPPT 535
                  |:.||.:.:.::..||.   |:  ||..||         .:.:.:....|..|
 Worm   333 ------EKFDSMAKKMQSVVLTGRTRDYLVRGIKESMRIAGGAAGNVVDALNDDWCTYS------ 385

  Fly   536 RLGMLTSRNRRP-------------------RNRRHGLWSMKLLGLFDWRRRRKPPRA------- 574
                 |...|:.                   |||..||            :..|.||.
 Worm   386 -----TENGRKSFSAMVGDIFERAGNAISPRRNRYRGL------------KTEKSPRGYGKPDTV 433

  Fly   575 ---------------DSDEDEDDEQTQLRANEA----PTTSAAAAAAQAAAQAARISPP-----T 615
                           |.|..||||   :..|.|    ...|.....|.::::..:.|..     |
 Worm   434 QDILSERIKFIDNEFDFDTKEDDE---IPGNMAMSIYDNVSCRKDEADSSSEETKFSTKPKRNGT 495

  Fly   616 GGRRRMSYYRREEMEARRKGKR----TPQYNSVS--------KIDRASRIVFPLLFILINVFYWY 668
            .|.|:..     :....:.|:.    ...|..:|        |||::.|.:||..|:|.|||||:
 Worm   496 NGTRKYI-----DKSLNQSGQNDSLIVATYFQISANHSRHALKIDKSCRYLFPAAFLLWNVFYWW 555

  Fly   669 GYLSRSSRILANTP 682
            .||     :...||
 Worm   556 YYL-----VYTKTP 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	52/217 (24%)
		LIC	111..670	CDD:273305	151/636 (24%)
		Neur_chan_memb	398..667	CDD:280999	84/344 (24%)
lgc-41	NP_001360683.1	LIC	41..>332	CDD:273305	96/358 (27%)
		LGIC_TM	<527..557	CDD:365787	13/29 (45%)
		TM4 helix	530..554	CDD:349850	11/23 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910