Protein Alignment Grd and glc-4

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_495489.2
• Gene: glc-4 / 182971
• WormBaseID: WBGene00001594
• Length: 500
• Species: Caenorhabditis elegans
• Alignment Length: 587
• Identity: 151/587 - (25%)
• Similarity: 230/587 - (39%)
• Gaps: 152/587 - (25%)

  Fly   115 NLLRGYDNSIRPDFGGPP-------ATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE 172
            :||:.||.::||. |..|       ..:...:.:||:..:||.:|.:.....|||.|.|.||.|.
 Worm    50 DLLQDYDAAVRPS-GRTPYNDTRGAVMVTTSLNIRSISAVSEKNMEFVAQFRFRQEWYDDRLRFI 113

  Fly   173 GAQDTLA--------LSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTI 229
            ..|..|:        :.|:....:|.|||:|.|.|..:.|.:...|:|::|..:|:::|..|||:
 Worm   114 EHQGLLSSDYRNFEFIHVARDQSLWIPDTFFQNEKNGWYHMLNQENRFLKIRSDGKLIYDRRLTL 178

  Fly   230 KAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLT 294
            ...|.|:|:.:|||.|.|.:.|.|:.|||:|:.|.|  :.|.:.|.|..
 Worm   179 HLACSMHLSRYPMDHQNCEIAFASYAYTTADIEYIW--DVPAIQIHEGA---------------- 225

  Fly   295 DIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSG 359
                ..|.|..:...|.|..   .|||..|
 Worm   226 ----NGALPNFEIASFKNAS---CTSKTNT----------------------------------- 248

  Fly   360 STTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRV 424
                  ||          ||.|.|...|.|....||:|:|.|..:||.::|||:|::.::||.||
 Worm   249 ------GT----------YSCLKVEIRLNRVFSFFLLQLYIPSSMLVGVAWVSYWIDWKSTAARV 297

  Fly   425 SLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFI 489
            .|.|.|:|||........::||.|||..::|.:|.....|||.:::::|||:|
 Worm   298 PLAIVTLLTMITTSHAINSNLPPVSYAKSIDIWVGACVVFIFFSLIEYAVVNY------------ 350

  Fly   490 IEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGL 554
            :..||......:.        ....|::..||.......|          |.|....|:.::
 Worm   351 VGILDEHRQMKKA--------ACNRSRLSNVIENDNFGES----------LQSLTFSPQEKK--- 394

  Fly   555 WSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRR 619
                       |..|:.|:.:.:..|.|.:.....:..|..||..................|.|:
 Worm   395 -----------RLIRRRPKKNMEMQEGDFEAIEMVDRGPPRSAGLMEEGWTFHDTTDLVYIGQRK 448

  Fly   620 RMSYYR-REEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLSRSSRILANTPD 683
            |:...| ...:.:|.:.:|         ||..:||:|||.|||.|..||..||....      ||
 Worm   449 RVELVRWCSVLSSRGRAER---------IDIIARIIFPLAFILFNFAYWSIYLEEED------PD 498

  Fly   684 AS 685
            .|
 Worm   499 ES 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	146/570 (26%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	52/182 (29%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)
glc-4	NP_495489.2	LIC	26..491	CDD:455710	146/570 (26%)