Protein Alignment Grd and acc-1

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001293865.1
• Gene: acc-1 / 177799
• WormBaseID: WBGene00010275
• Length: 470
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 136/600 - (22%)
• Similarity: 222/600 - (37%)
• Gaps: 163/600 - (27%)

  Fly    81 THRLGEMGTSLSSSLPSSWLTQSNNHANISELLDNLLR-GYDNSIRPDFGGPPATIEVDIMVRSM 144
            |..|.:....::.||        :|.||.:|:::.||: .|:....|..   |..:.||:.|:.:
 Worm    17 TELLSQSSKGIAQSL--------DNCANDTEIINALLKDSYNKHYIPSH---PTHVRVDMWVQEV 70

  Fly   145 GPISEVDMTYSMDCYFRQSWVDKRLAFEG---AQDTLALSVSMLARIWKPDTYFYNGKQSYLHTI 206
            ..:||:...:.:|.|..:.|.|..|.:|.   .:..::....:|.|:|.|:|.|.|.|.:.:|..
 Worm    71 TSVSELTQDFEIDLYINEFWEDPALVYEDMNPCKRNISFDDKVLQRLWLPNTCFINSKSAAIHES 135

  Fly   207 TTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPP 271
            ...|.|:.::.||.:..:.|:.:...|.|.|..||.|.|||.|.|.||.|.|.:|..:||:.. |
 Worm   136 PFKNVFLMVFSNGTLWTNYRMKLTGPCDMKLKRFPFDKQKCYLTFESFNYNTGEVRMQWNQPY-P 199

  Fly   272 VAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHV 336
            |.:.:.::|..|.||:
 Worm   200 VILLKRIELPDFKLVN------------------------------------------------- 215

  Fly   337 RGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSE-YSMLMVNFHLQRHMGNFLIQVYG 400
                                        ...|.:|..:|:. :..|.|.|..:|..|.:::|.|.
 Worm   216 ----------------------------FSVIAVEQMYPAGWWDELTVAFVFERRYGWYVLQGYI 252

  Fly   401 PCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFI 465
            |..:.:|:||:||:|...|...|..||:.::|.|||.......:||:|||..|:|.::.....||
 Worm   253 PTMVTIVISWISFYLGPRAIPARTMLGVNSLLAMTFQFGNIIRNLPRVSYVKAIDVWMLSGMLFI 317

  Fly   466 FATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISM 530
            |.::|:.|||.:.                     |..|.|
 Worm   318 FLSLLELAVVGFM---------------------SRNEGL------------------------- 336

  Fly   531 PPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTT 595
             ||..:      :.:|..:...|         |.|:..:..|..:..:...|:    |.|.....
 Worm   337 -PPKVK------KRKRQEDDDEG---------FSWKSMQTSPHLELRQFWVDK----RVNSLRND 381

  Fly   596 SAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFI 660
            ||.......|............:||   .:|:.|...||..|..:......:|..|.|.||..::
 Worm   382 SAVPPVEDYAPMELEQPYQNITKRR---EKRKWMSGLRKKWRAMRELRPETVDFYSAIFFPTAYM 443

  Fly   661 LINVFYWYGYLSRSS 675
            |.|:.||..||:..|
 Worm   444 LFNISYWSFYLTSLS 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	126/563 (22%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	50/170 (29%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)
acc-1	NP_001293865.1	LIC	39..453	CDD:455710	126/563 (22%)
		LGIC_ECD_GABAAR	59..242	CDD:349791	55/260 (21%)
		Cys-loop	162..176	CDD:349791	7/13 (54%)