Protein Alignment Grd and gab-1

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_499661.2
• Gene: gab-1 / 176691
• WormBaseID: WBGene00001512
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 694
• Identity: 195/694 - (28%)
• Similarity: 286/694 - (41%)
• Gaps: 214/694 - (30%)

  Fly    37 RIFKLLISCCLLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLT 101
            |||.:.|:..|:......|        |:.|.:                   .|.|..:.|||..
 Worm     8 RIFHVSITLLLVSTIFCQN--------GTKPHN-------------------NSTSDQMSSSWSN 45

  Fly   102 QSNN-HANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWV 165
            :|.. ::|.|.||.:||..||..:||.|||....:.:||::.|...||||||.|::..|..|.|.
 Worm    46 RSQTMYSNASSLLSDLLLDYDIRLRPGFGGDALLLTMDIIIASFDSISEVDMDYTLTMYLHQYWT 110

  Fly   166 DKRLAF--EGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLT 228
            |:||.:  |...|.:.||......||.|||:..|.|.||||.:|..||.:||..:|:|.|..|||
 Worm   111 DERLRWSNEIPIDEMTLSGEFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGMRLT 175

  Fly   229 IKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAI--AEDMKLSQFDLVDCPAG 291
            ....|.|||.:||:|.|.|.::..|:|||||:|:.:||.   |:|:  .|...:.||.:..
 Worm   176 STLSCSMNLRNFPLDSQNCTVEIESYGYTTSEVLMKWNY---PLAVHGVEQADVPQFTITG---- 233

  Fly   292 NLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATG 356
                              |:.:|      .:::|                            |||
 Worm   234 ------------------FHTED------SIVST----------------------------ATG 246

  Fly   357 GSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATA 421
                                .|..|.:.|.|:|.:|.|:.|.|.||.|:|:|||||||:|.|||:
 Worm   247 --------------------SYQRLSLVFQLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATS 291

  Fly   422 DRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHY------YTK 480
            .||:||||||||||.:....|..||::||..::|.::.:.|.|:||.:|::|.|:|      ..|
 Worm   292 ARVALGITTVLTMTTISTGVRQSLPRISYVKSIDIYLVMCFVFVFAALLEYAAVNYSYWGRERGK 356

  Fly   481 YGSGECYFI---------------------------------IEELDSESGESETEPLTSDFRGS 512
            .|.|..:.:                                 :|.|:.....|.|....::|..:
 Worm   357 GGGGNEWPVNGANKEDRESAVNVQKWVPSGLMDGVPQPQDRRVEALEEAMSTSNTAAQNNNFEST 421

  Fly   513 TESKIYEVIPLSMCAISMPPPPTRLG-MLTSRNRRPRNRRHGLWSMK--------------LLGL 562
            ::.|.....|:        ||..|.| .::..:..|...|:...|:|              |.|.
 Worm   422 SKPKKRSSSPI--------PPLCRAGNTISEESESPDYPRYSTTSLKGARPHASLNHKTHHLKGR 478

  Fly   563 FDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRRE 627
            ...|.:|:             .|..|.|.:...|.:..                |||
 Worm   479 SSARAKRR-------------MTLARMNVSMKQSISGI----------------GRR-------- 506

  Fly   628 EMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYL 671
                .||...|.:...|:.||:.||:|||:.||:.|:|||..|:
 Worm   507 ----ARKVIPTIRVRDVNLIDKYSRVVFPVCFIVFNLFYWSYYM 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	79/219 (36%)
		LIC	111..670	CDD:273305	178/616 (29%)
		Neur_chan_memb	398..667	CDD:280999	86/322 (27%)
gab-1	NP_499661.2	LIC	67..545	CDD:273305	172/605 (28%)
		Neur_chan_LBD	68..259	CDD:280998	80/269 (30%)
		Neur_chan_memb	268..542	CDD:280999	86/322 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810