Protein Alignment Grd and Glrb

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_036018791.1
• Gene: Glrb / 14658
• MGIID: 95751
• Length: 530
• Species: Mus musculus
• Alignment Length: 625
• Identity: 162/625 - (25%)
• Similarity: 236/625 - (37%)
• Gaps: 224/625 - (35%)

  Fly   110 SELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLA---- 170
            |.:|:.||..||..|||:|.|.|..:.|:|.:.|.|.|.|..|.|.::.:.||.|.|.||.
Mouse    67 SNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSD 131

  Fly   171 FEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPM 235
            |.|: |.|.:..:|...:||||.:|.|.|.:..|.:|..|..:.|:::|.||.|.||:|...||:
Mouse   132 FRGS-DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPL 195

  Fly   236 NLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDL--VDCPAGNLTDIVY 298
            :|..||||.|:|.::..||||||.|:.:.| :...||.: |.:.|.|||:  .|...||.|
Mouse   196 DLTLFPMDTQRCKMQLESFGYTTDDLRFIW-QSGDPVQL-EKIALPQFDIKKEDIEYGNCT---- 254

  Fly   299 KAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTG 363
                                               ::.:|||.
Mouse   255 -----------------------------------KYYKGTGY---------------------- 262

  Fly   364 LSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGI 428
                          |:.:.|.|.|:|.:|.:::.||.|..|:|||||:|||:|.:|:|.||.|||
Mouse   263 --------------YTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGI 313

  Fly   429 TTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYY--------------- 478
            .:||::.........:||||||..|||.::.....|.||:::::|||...
Mouse   314 FSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIA 378

  Fly   479 ----------------TKYGSGE-------------CYFIIEELDSESGESETEPLTSDFRGSTE 514
                            |..|:|.             |..|..:||.    ..|:.||:.. |.|.
Mouse   379 KAEQADGKGGNAAKKNTVNGTGTPVHISTLQELPMVCQQITYQLDG----WPTDTLTTQV-GETR 438

  Fly   515 SKIYEVIPLSMCAISMPPPPTRLGMLTSRNR-----------RPRNRRHGLWSMKLLGLFDWRRR 568
            .|       .:|............::.|..|           :|....:||...:       .:.
Mouse   439 CK-------KVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQ-------AKN 489

  Fly   569 RKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISP--PTGGRRRMSYYRREEMEA 631
            :|||.|                                     .|  ||..:|
Mouse   490 KKPPPA-------------------------------------KPVIPTAAKR------------ 505

  Fly   632 RRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYL 671
                           ||..:|.:||..|:..||.||..||
Mouse   506 ---------------IDLYARALFPFCFLFFNVIYWSIYL 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	159/621 (26%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	66/173 (38%)
		Cys-loop	233..247	CDD:349808	8/13 (62%)
Glrb	XP_036018791.1	LIC	64..529	CDD:455710	160/622 (26%)
		LGIC_ECD_GlyR_beta	89..275	CDD:349811	73/263 (28%)
		Cys-loop	193..207	CDD:349811	8/13 (62%)