Protein Alignment Grd and Glra4

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_034427.2
• Gene: Glra4 / 14657
• MGIID: 95750
• Length: 456
• Species: Mus musculus
• Alignment Length: 666
• Identity: 186/666 - (27%)
• Similarity: 258/666 - (38%)
• Gaps: 262/666 - (39%)

  Fly    42 LISCCLLMLCIYPNAWPWSIGPGSGPFSV--SADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSN 104
            |:...|.:|.       |:: ||....||  :.:.:|            :.|..|.|.|
Mouse     4 LVPASLFLLL-------WTL-PGKVLLSVALAKEDVK------------SGLKGSQPMS------ 42

  Fly   105 NHANISELLDNLL---RGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVD 166
                .|:.||.|:   .|||..|||:|.|||..:..:|.:.|.|.::|..|.|.::.:.||.|.|
Mouse    43 ----PSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNVFLRQQWND 103

  Fly   167 KRLAF-EGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIK 230
            .|||: |...|:|.|..|||..|||||.:|.|.|.:..|.:||.||.:||::||.||||.|||:.
Mouse   104 PRLAYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLI 168

  Fly   231 AGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTD 295
            ..|||:|.:||||||.|.::..|||||.:|:::.|.::.|.|.:||.:.|.||.|.|
Mouse   169 LSCPMDLKNFPMDIQTCTMQLESFGYTMNDLMFEWLEDAPAVQVAEGLTLPQFILRD-------- 225

  Fly   296 IVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGS 360
                            .||            .|...|:              :.||:
Mouse   226 ----------------EKD------------LGYCTKH--------------YNTGK-------- 240

  Fly   361 TTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVS 425
                             ::.:.|.|||:|.||.:|||:|.|..|:|:|||||||:|.:|...||.
Mouse   241 -----------------FTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVG 288

  Fly   426 LGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVH-------------- 476
            ||||||||||.....:|..||||||..|:|.::.:...|:||.:|::|.|:
Mouse   289 LGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFMRLRR 353

  Fly   477 -----------------YYTKYGSGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLS 524
                             |:..||.|.|      |.:..|.                      |:.
Mouse   354 RQRRQRMEEDIIRESRFYFRGYGLGHC------LQARDGG----------------------PME 390

  Fly   525 MCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRA 589
            ..:|..|.|||.|                                                 |:.
Mouse   391 GSSIYSPQPPTPL-------------------------------------------------LKE 406

  Fly   590 NEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIV 654
            .|.                          .|..|..|                 ..:||..||.|
Mouse   407 GET--------------------------MRKLYVDR-----------------AKRIDTISRAV 428

  Fly   655 FPLLFILINVFYWYGY 670
            ||..|::.|:|||..|
Mouse   429 FPFTFLVFNIFYWVVY 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	87/219 (40%)
		LIC	111..670	CDD:273305	171/593 (29%)
		Neur_chan_memb	398..667	CDD:280999	69/299 (23%)
Glra4	NP_034427.2	LIC	9..444	CDD:273305	184/659 (28%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		2/29 (7%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810