Protein Alignment Grd and Gabra6

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_036012221.1
• Gene: Gabra6 / 14399
• MGIID: 95618
• Length: 459
• Species: Mus musculus
• Alignment Length: 487
• Identity: 176/487 - (36%)
• Similarity: 258/487 - (52%)
• Gaps: 108/487 - (22%)

  Fly   108 NISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE 172
            |:|.:|||||.||||.:||.|||....::.||.|.|.||:|:|:|.|:||.:|||:|.|:||.|:
Mouse    31 NVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFK 95

  Fly   173 GAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNL 237
            |..:.|:|:..|:::||.|||:|.|||:|..|.:|||||..|:.|||.:||:.||||.|.|||.|
Mouse    96 GPAEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRL 160

  Fly   238 ADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAI---AEDMKLSQFDLVDCPAGNLTDIVYK 299
            .:||||...|||||||:.|..:::||.| |:.|..::   .|...|.|:||:
Mouse   161 VNFPMDGHACPLKFGSYAYPKTEIIYTW-KKGPLYSVEVPEESSSLLQYDLI------------- 211

  Fly   300 AAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGL 364
                                        |....::.::                      |.||
Mouse   212 ----------------------------GQTVSSETIK----------------------SNTG- 225

  Fly   365 SGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGIT 429
                        ||.::.|.|||||.||.|:||:|.||.:.|:||.||||:|:|:...|...|||
Mouse   226 ------------EYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGIT 278

  Fly   430 TVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELD 494
            ||||||.|.:.||..||||||.||:|:|:.:.|.|:|:.:::||.|:|:|...|       ::.:
Mouse   279 TVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQS-------QKAE 336

  Fly   495 SESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKL 559
            .::..:.|.|:...  .::||...|::      ::.||...|......|.||.|.||.
Mouse   337 RQAQTAATPPVAKS--KASESLQAEIV------VTAPPQKRRRRRRRRRRRRRRRRRR------- 386

  Fly   560 LGLFDWRRRRKPPRADSDEDEDDEQTQLRANE 591
                  ||||:..:.:.:|:|::|:.:....|
Mouse   387 ------RRRRRRRKKEEEEEEEEEEEEEEEEE 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	174/484 (36%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	77/170 (45%)
		Cys-loop	233..247	CDD:349808	8/13 (62%)
Gabra6	XP_036012221.1	LGIC_ECD_GABAAR_A6	42..239	CDD:349840	97/273 (36%)
		Cys-loop	156..170	CDD:349840	8/13 (62%)
		LGIC_TM_GABAAR_alpha	242..337	CDD:349854	47/101 (47%)
		TM1 helix	242..265	CDD:349854	13/22 (59%)
		TM2 helix	269..293	CDD:349854	13/23 (57%)
		TM3 helix	301..327	CDD:349854	10/25 (40%)