Protein Alignment Grd and Gabra2

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_032092.1
• Gene: Gabra2 / 14395
• MGIID: 95614
• Length: 451
• Species: Mus musculus
• Alignment Length: 597
• Identity: 192/597 - (32%)
• Similarity: 270/597 - (45%)
• Gaps: 200/597 - (33%)

  Fly   104 NNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKR 168
            ||....:.:||.||.||||.:||..|.....:..:|.|.|.||:|:.||.|::|.:|||.|.|:|
Mouse    37 NNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDER 101

  Fly   169 LAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGC 233
            |.|:|..:.|.|:..|.::||.|||:|:|||:|..|.:|.|||.:||..:|.:||:.|||::|.|
Mouse   102 LKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAEC 166

  Fly   234 PMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWN-KERPPVAIAED-MKLSQFDLVDCPAGNLTDI 296
            ||:|.|||||...|||||||:.||||:|.|.|. .....|.:|.| .:|:|:||:....|..|
Mouse   167 PMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKET-- 229

  Fly   297 VYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGST 361
                                                        :|                 |:
Mouse   230 --------------------------------------------IK-----------------SS 233

  Fly   362 TGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSL 426
            ||             ||:::..:|||:|.:|.|:||.|.||.:.|:||.||||||||:...|...
Mouse   234 TG-------------EYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVF 285

  Fly   427 GITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYG---SGECYF 488
            |:|||||||.|.:.||..||||:|.||:|:|:.:.:.|:|:.:::||.|:|:||.|   .|:.
Mouse   286 GVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKS-- 348

  Fly   489 IIEELDSESGE-------------SETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGML 540
            ::.:...|.|.             :....|:.|...||.||          :.:.|.|
Mouse   349 VVNDKKKEKGSVMIQNNAYAVAVANYAPNLSKDPVLSTISK----------SATTPEP------- 396

  Fly   541 TSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAA 605
               |::|.|                    ||..|
Mouse   397 ---NKKPEN--------------------KPAEA------------------------------- 407

  Fly   606 AQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGY 670
                                          |:|  :||||||||.||||||:||...|:.||..|
Mouse   408 ------------------------------KKT--FNSVSKIDRMSRIVFPVLFGTFNLVYWATY 440

  Fly   671 LSRSSRILANTP 682
            |:|.. :|..:|
Mouse   441 LNREP-VLGVSP 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	89/217 (41%)
		LIC	111..670	CDD:273305	185/576 (32%)
		Neur_chan_memb	398..667	CDD:280999	80/284 (28%)
Gabra2	NP_032092.1	LIC	25..440	CDD:273305	187/583 (32%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	97/277 (35%)
		Cys-loop	166..180	CDD:349836	9/13 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..408		9/119 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2083
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.160