Protein Alignment Grd and Gabra4

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_542154.3
• Gene: Gabra4 / 140675
• RGDID: 621670
• Length: 552
• Species: Rattus norvegicus
• Alignment Length: 626
• Identity: 201/626 - (32%)
• Similarity: 278/626 - (44%)
• Gaps: 186/626 - (29%)

  Fly   108 NISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE 172
            |.:.:||:||.||||.:||.||||...::.||.|.|.||:|:|:|.|:||.:|||:|:||||.::
  Rat    47 NFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111

  Fly   173 GAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNL 237
            |..:.|.|:..|:.::|.|||:|.|||:|..|.:|.|||..||.:||.:||:.||||.|.|||.|
  Rat   112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRL 176

  Fly   238 ADFPMDIQKCPLKFGSFGYTTSDVIYRWNK--ERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKA 300
            .|||||...|||||||:.|..|::||.|.|  |:......|...|.|:||:
  Rat   177 VDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLI-------------- 227

  Fly   301 AAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLS 365
                                       |....::.::                      |.||
  Rat   228 ---------------------------GQTVSSETIK----------------------SITG-- 241

  Fly   366 GTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITT 430
                       ||.::.|.|||:|.||.|:||.|.||.:.|:||.||||:|:|:...|...||||
  Rat   242 -----------EYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITT 295

  Fly   431 VLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDS 495
            |||||.|.:.||..||||||.||:|:|:.:.|.|:|:.:::||.|:|:|            .:..
  Rat   296 VLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT------------NIQM 348

  Fly   496 ESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPP--PTRLGMLTSRNRRPRNRRHGLWSMK 558
            :..:.:                          ||.|||  |....:............|...:|
  Rat   349 QKAKKK--------------------------ISKPPPEVPAAPVLKEKHTETSLQNTHANLNM- 386

  Fly   559 LLGLFDWRRRRKPPRADSDED------------------EDDEQTQ-----------LRANEAPT 594
                    |:|......|:.|                  |..|.|.           .|||.|.|
  Rat   387 --------RKRTNALVHSESDVNSRTEVGNHSSKTTAAQESSETTPKAHLASSPNPFSRANAAET 443

  Fly   595 TSAAAAAAQAAAQAARISPPTGGRRRMSYYR----REEMEARRKGKRT----------------- 638
            .||||....:||     ||...|..:.:..|    |....||....:|
  Rat   444 ISAAARGLSSAA-----SPSPHGTLQPAPLRSASARPAFGARLGRIKTTVNTTGVPGNVSATPPP 503

  Fly   639 ----PQYNSVSKIDRASRIVFPLLFILINVFYWYGYLSRSS 675
                |..:..||||:.:||:||:.|...|:.||..|||:.:
  Rat   504 SAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDT 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	91/217 (42%)
		LIC	111..670	CDD:273305	197/616 (32%)
		Neur_chan_memb	398..667	CDD:280999	88/324 (27%)
Gabra4	NP_542154.3	LIC	13..539	CDD:273305	198/619 (32%)
		Neur_chan_LBD	49..256	CDD:280998	102/282 (36%)
		Neur_chan_memb	263..536	CDD:280999	88/324 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..436		15/117 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..470		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	486..513		2/26 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I2964
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2041
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105663
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.960