Protein Alignment Grd and Gabra5

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_795916.1
• Gene: Gabra5 / 110886
• MGIID: 95617
• Length: 463
• Species: Mus musculus
• Alignment Length: 596
• Identity: 193/596 - (32%)
• Similarity: 276/596 - (46%)
• Gaps: 173/596 - (29%)

  Fly    93 SSLP-SSWLTQSNNHANI-SELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYS 155
            |.:| ||...::|::..| :.:||.||.||||.:||..|.....:..||.|.|.||:|:.:|.|:
Mouse    31 SQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYT 95

  Fly   156 MDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGR 220
            :|.:|||||.|:||.|:|....|.|:..:.::||.|||:|:|||:|..|.:|||||.:|:..:|.
Mouse    96 IDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGT 160

  Fly   221 VLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRW-NKERPPVAIAED-MKLSQF 283
            :||:.||||.|.|||.|.|||||...|||||||:.|..|:|:|.| |.....|.:||| .:|:|:
Mouse   161 LLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQY 225

  Fly   284 DLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAF 348
            .|:
Mouse   226 HLM-------------------------------------------------------------- 228

  Fly   349 GTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSF 413
                      |.|.   ||..:.|: ..||:::..:|||:|.:|.|:||.|.||.:.|:||.|||
Mouse   229 ----------GQTV---GTENISTS-TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSF 279

  Fly   414 WLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYY 478
            |||||:...|...|:|||||||.|.:.||..||||:|.||:|:|:.:.:.|:|:.:::||.|:|:
Mouse   280 WLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF 344

  Fly   479 TKYG---SGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGML 540
            ||.|   .|:......::..:..|......|:.|                          ..|.|
Mouse   345 TKRGWAWDGKKALEAAKIKKKERELILNKSTNAF--------------------------TTGKL 383

  Fly   541 TSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAA 605
            |.....|                    :.:||...::              |||.|..|:..:.|
Mouse   384 THPPNIP--------------------KEQPPAGTAN--------------APTVSIKASEEKTA 414

  Fly   606 AQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGY 670
                                        :.|:|  |||:||||:.||||||:||...|:.||..|
Mouse   415 ----------------------------ESKKT--YNSISKIDKMSRIVFPILFGTFNLVYWATY 449

  Fly   671 LSRSSRILANT 681
            |:|...|...|
Mouse   450 LNREPVIKGAT 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	182/563 (32%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	76/169 (45%)
		Cys-loop	233..247	CDD:349808	9/13 (69%)
Gabra5	NP_795916.1	LIC	15..449	CDD:455710	188/583 (32%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	93/273 (34%)
		Cys-loop	173..187	CDD:349839	9/13 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..408		7/54 (13%)