DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grd and gabra3

DIOPT Version :9

Sequence 1:	NP_524131.1	Gene:	Grd / 39984	FlyBaseID:	FBgn0001134	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_021324929.1	Gene:	gabra3 / 100538116	ZFINID:	ZDB-GENE-091204-365	Length:	306	Species:	Danio rerio

Alignment Length:	398	Identity:	135/398 - (33%)
Similarity:	187/398 - (46%)	Gaps:	114/398 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IFKLLIS--CC---LLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPS 97
            :|..|.|  ||   ||.|...|              |....::.|    ||         ..:|.
Zfish     4 VFHKLTSCVCCVWILLSLLFNP--------------SSQTGAVTG----HR---------EPIPD 41

  Fly    98 SWLTQSNNHANISELLDNLLRGYDNSIRPDFGGPPAT-IEVDIMVRSMGPISEVDMTYSMDCYFR 161
            .   ..:|....:.:||.||.||||.:||..|....| :..:|.|.|.||:|:.||.|::|.:||
Zfish    42 D---SKDNITIFTRILDRLLDGYDNRLRPGLGAESVTEVRTNIYVTSFGPVSDTDMEYTIDVFFR 103

  Fly   162 QSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSR 226
            |||.|:||.|:|....|.|:..:.::||.|||:|:|||:|..|.:|||||.:|:..||.:||:.|
Zfish   104 QSWRDERLKFDGPMQVLPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMR 168

  Fly   227 LTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWN-KERPPVAIAED-MKLSQFDLVDCP 289
            |||.|.|||:|.|||||...|||||||:.||.::|:|.|. .:...|::|.| .:|:|:||:.
Zfish   169 LTIHAECPMHLEDFPMDAHACPLKFGSYAYTNNEVVYIWTADDEKSVSVAPDGSRLNQYDLLG-- 231

  Fly   290 AGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDA 354
                                                         ||             .|::.
Zfish   232 ---------------------------------------------HV-------------IGKET 238

  Fly   355 TGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREA 419
            .   .|:||             ||.::...|||:|.:|.|:||.|.||.:.|:||.||||||||:
Zfish   239 I---SSSTG-------------EYVVMTTYFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRES 287

  Fly   420 TADRVSLG 427
            ...|...|
Zfish   288 VPARTVFG 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	88/218 (40%)
		LIC	111..670	CDD:273305	120/320 (38%)
		Neur_chan_memb	398..667	CDD:280999	16/30 (53%)
gabra3	XP_021324929.1	Neur_chan_LBD	52..>295	CDD:332142	119/318 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2100
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.160