Protein Alignment Grd and gabra3

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_002939243.2
• Gene: gabra3 / 100494398
• XenbaseID: XB-GENE-992774
• Length: 538
• Species: Xenopus tropicalis
• Alignment Length: 683
• Identity: 209/683 - (30%)
• Similarity: 303/683 - (44%)
• Gaps: 228/683 - (33%)

  Fly    22 AARSLSSH---QGQRSNLRIFKLLISCCLLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHR 83
            |.|||..|   :|| .::.:..|:....||.:|:.|
 Frog    61 AQRSLRKHIMARGQ-EDISLLSLVALGILLRMCLLP----------------------------- 95

  Fly    84 LGEMGTSLSSSLPSSWLTQSNNHANI-SELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPI 147
               .|..||:......:..|.::..| :.:||.||.||||.:||..|.....::.||.|.|.||:
 Frog    96 ---AGKGLSAKHAPEVVDDSRDNITIFTRILDRLLDGYDNRLRPGLGDSVTEVKTDIYVTSFGPV 157

  Fly   148 SEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKF 212
            |:.||.|::|.:|||||:|:||.|:|...||.|:..:.::||.|||:|:|||:|..|.:|||||.
 Frog   158 SDTDMEYTIDVFFRQSWLDERLKFDGPIRTLPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKL 222

  Fly   213 VRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRW-NKERPPVAIAE 276
            :|:..||.:||:.||||.|.|.|:|.|||||:..|||||||:.|..::|:|.| |.....||:|.
 Frog   223 LRLIDNGTLLYTMRLTIHAECTMHLEDFPMDVHACPLKFGSYAYPKTEVVYSWTNGSNKSVAVAP 287

  Fly   277 D-MKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTG 340
            | .:|:|:||:                                         |.|...:.:|
 Frog   288 DGSRLNQYDLL-----------------------------------------GVAVGTETIR--- 308

  Fly   341 LKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLL 405
                               |:||             ||.::..:|||:|.:|.|:||.|.||.:.
 Frog   309 -------------------SSTG-------------EYIVMTTHFHLKRKIGYFVIQTYLPCIMT 341

  Fly   406 VVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATIL 470
            |:||.||||||||:...|...|:|||||||.|.:.||..||||:|.||:|:|:.:.:.|:|:.::
 Frog   342 VILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFMAVCYAFVFSALI 406

  Fly   471 QFAVVHYYTKYGSGECYFIIEELDSESGE-----SETEPL--------TSDFRGSTES---KIYE 519
            :||.|:|:||.|..        .|.:.|:     .:.||:        |.:..|:|.:   |...
 Frog   407 EFATVNYFTKRGWA--------WDGKRGQEGQDFKKKEPIILAKKSNTTYNIVGTTYTLNIKEPA 463

  Fly   520 VIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQ 584
            :..::..|...||||            |.:.||              ...||
 Frog   464 LATIAKSAALQPPPP------------PLSPRH--------------LEHKP------------- 489

  Fly   585 TQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDR 649
                                                        ||.::      .|||||:||:
 Frog   490 --------------------------------------------MECKK------TYNSVSRIDK 504

  Fly   650 ASRIVFPLLFILINVFYWYGYLSRSSRILANTP 682
            .||||||:||.:.|:.||..|::|.|.|....|
 Frog   505 ISRIVFPVLFAIFNLVYWATYVNRESAIKGIIP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	89/217 (41%)
		LIC	111..670	CDD:273305	187/576 (32%)
		Neur_chan_memb	398..667	CDD:280999	80/284 (28%)
gabra3	XP_002939243.2	LIC	121..525	CDD:273305	187/576 (32%)
		LGIC_ECD_GABAAR_A3	127..326	CDD:349837	97/274 (35%)
		Cys-loop	243..257	CDD:349837	8/13 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2891
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20218
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2061
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160