Protein Alignment Grd and gabra5

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_004911866.1
• Gene: gabra5 / 100494208
• XenbaseID: XB-GENE-980292
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 608
• Identity: 194/608 - (31%)
• Similarity: 280/608 - (46%)
• Gaps: 176/608 - (28%)

  Fly    87 MGTSLSSSLPSSWLTQSNNHANI---SELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPIS 148
            :.|:.|.|..::...:.:.:.||   :.:||.||.||||.:||..|.....::.||.|.|.||:|
 Frog    28 LATNFSMSQTTAAPVKEDTNDNITIFTRILDGLLDGYDNRLRPGLGERITQVKTDIYVTSFGPVS 92

  Fly   149 EVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFV 213
            :.:|.|::|.:|||||.|:||.|:|....|.|:..:.::||.|||:|:|||:|..|.||||||.:
 Frog    93 DTEMEYTIDVFFRQSWKDERLCFQGPMPRLPLNNLLASKIWTPDTFFHNGKKSIAHNITTPNKLL 157

  Fly   214 RIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRW-NKERPPVAIAED 277
            |:..:|.:||:.||||.|.|||.|.|||||...|||||||:.|..|::.|.| |.....|.:|||
 Frog   158 RLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSELRYEWTNITDKSVVVAED 222

  Fly   278 -MKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGL 341
             .:|:|:.|:
 Frog   223 GSRLNQYHLI------------------------------------------------------- 232

  Fly   342 KLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLV 406
                             |.|.   ||..:.|: ..||:::..:|||:|.:|.|:||.|.||.:.|
 Frog   233 -----------------GQTV---GTENISTS-TGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTV 276

  Fly   407 VLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQ 471
            :||.||||||||:...|...|:|||||||.|.:.||..||||:|.||:|:|:.:.:.|:|:.:::
 Frog   277 ILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIE 341

  Fly   472 FAVVHYYTKYG---SGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPP 533
            ||.|:|:||..   .|:......::..:..||
 Frog   342 FATVNYFTKRSWAWDGKKALEAAKIKKKEQES--------------------------------- 373

  Fly   534 PTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAA 598
               ||      |:|.|...|               |.|...:..:|             .|:|..
 Frog   374 ---LG------RKPINSYSG---------------RIPYTPNMSKD-------------LTSSVI 401

  Fly   599 AAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILIN 663
            |.||                   |.:.:...|...:.|:|  ||||||||:.||||||::|...|
 Frog   402 ANAA-------------------SIHMKTTEEKCAESKKT--YNSVSKIDKMSRIVFPVMFGTFN 445

  Fly   664 VFYWYGYLSRSSRILANTPDAST 686
            :.||..||:|.. ::.....|.|
 Frog   446 LVYWATYLNREP-VIKGAASAKT 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	87/217 (40%)
		LIC	111..670	CDD:273305	184/563 (33%)
		Neur_chan_memb	398..667	CDD:280999	80/271 (30%)
gabra5	XP_004911866.1	LIC	25..452	CDD:273305	189/590 (32%)
		LGIC_ECD_GABAAR_A5	62..260	CDD:349839	93/273 (34%)
		Cys-loop	177..191	CDD:349839	9/13 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2891
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2061
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.160