Protein Alignment Grd and gabrb1

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_012811146.2
• Gene: gabrb1 / 100489344
• XenbaseID: XB-GENE-6049110
• Length: 477
• Species: Xenopus tropicalis
• Alignment Length: 618
• Identity: 173/618 - (27%)
• Similarity: 270/618 - (43%)
• Gaps: 164/618 - (26%)

  Fly    74 SIKGRGDTHRLGEMGTSLSSSLP--------SSWLTQSNNHANISELLDNLLRGYDNSIRPDFGG 130
            :::|||....|         |||        :..:.:.:|.:.:.|.:|.||:|||..:||||||
 Frog     3 TLRGRGYFGML---------SLPVMIAMVCCAQSVNEPSNMSYVKETVDRLLKGYDIRLRPDFGG 58

  Fly   131 PPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYF 195
            |...:.:.|.|.|:..:|||:|.|::..||:|||.||||::.|....|.|...:..::|.|||||
 Frog    59 PSVEVGMRIDVASIDMVSEVNMDYTLTMYFQQSWRDKRLSYSGIPLNLTLDNRVADQLWVPDTYF 123

  Fly   196 YNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSD 260
            .|.|:|::|.:|..|:.:|::.:|.|||..|:|..|.|.|:|..:|:|.|.|.|:..|:||||.|
 Frog   124 LNDKRSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDD 188

  Fly   261 VIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTT 325
            :.:.||.....:...|.::|.||.::|          ||..
 Frog   189 IKFYWNGGDKAITGVEKIELPQFSIID----------YKMV------------------------ 219

  Fly   326 FAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRH 390
                   :::|          .|.||                         .|..|.::|.|:|:
 Frog   220 -------SRNV----------IFSTG-------------------------AYPRLSLSFRLKRN 242

  Fly   391 MGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALD 455
            :|.|::|.|.|..|:.:|||||||:|.:|:|.||:||||||||||.:....|..|||:.|..|:|
 Frog   243 IGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAID 307

  Fly   456 FFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEV 520
            .::...|.|:|..:|::|.|:|.. :|.|      .:|..::.|            ..|....|.
 Frog   308 IYLMGCFVFVFLALLEYAFVNYIF-FGKG------PQLQKKAAE------------KAEKANNEK 353

  Fly   521 IPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQT 585
            ..|.|..:.:.                   .||...:..|.|                     :.
 Frog   354 TKLEMNKVQVD-------------------AHGNILLTTLEL---------------------RN 378

  Fly   586 QLRANEAPTTSAAAAAAQAAAQAARIS--PPTGGRRRMSYYRREEMEARRKGK----------RT 638
            ::..:|..|:.:...|...:..:|.|.  .|...|...|....:.....:||:          :.
 Frog   379 EVSGSEVLTSISDPRATMFSYDSASIQYRKPVANRDMYSRSTLDRHVVHKKGRLRRRASQIKIKI 443

  Fly   639 PQYNSVSKIDRASRIVFPLLFILINVFYWYGYL 671
            |....|:.|||.||::||:.|...||.||..|:
 Frog   444 PDLTDVNGIDRWSRMIFPVAFAFFNVVYWLYYI 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	164/570 (29%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	62/167 (37%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
gabrb1	XP_012811146.2	LIC	9..475	CDD:273305	169/609 (28%)