Protein Alignment Grd and gabrb3

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001096164.1
• Gene: gabrb3 / 100124708
• XenbaseID: XB-GENE-6030743
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 622
• Identity: 180/622 - (28%)
• Similarity: 264/622 - (42%)
• Gaps: 189/622 - (30%)

  Fly    84 LGEMGTSLSSSLPSSWLTQS-NNHANIS---ELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSM 144
            ||.:...:..|:..|  ||| |:..|:|   |.:|.||:|||..:||||||.|..:.::|.:.|:
 Frog    10 LGLISVPILISMVCS--TQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGSPVAVGMNIDIASI 72

  Fly   145 GPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTP 209
            ..:|||:|.|::..||:|.|.|||||:.|....|.|...:..::|.|||||.|.|:|::|.:|..
 Frog    73 DMVSEVNMDYTLTMYFQQYWRDKRLAYTGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVK 137

  Fly   210 NKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAI 274
            |:.:|::.:|.|||..|:|..|.|.|:|..:|:|.|.|.|:..|:||||.|:.:.|......|..
 Frog   138 NRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWLGGDNAVTG 202

  Fly   275 AEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGT 339
            .|.::|.||.::|          :|.                             .:||.
 Frog   203 VERIELPQFSIMD----------HKL-----------------------------VSKNV----- 223

  Fly   340 GLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCL 404
                   .|.||                         .|..|.::|.|:|::|.|::|.|.|..|
 Frog   224 -------VFATG-------------------------SYPRLSLSFKLKRNIGYFILQTYMPSIL 256

  Fly   405 LVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATI 469
            :.:|||||||:|.:|:|.||:||||||||||.:....|..|||:.|..|:|.::...|.|:|..:
 Frog   257 ITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLAL 321

  Fly   470 LQFAVVHY-----------------------YTKYGS------GECYFIIEELDSESGESETEPL 505
            |::|.|:|                       ::|:.|      |.......|:.:|...:|....
 Frog   322 LEYAFVNYIFFGRGPQMQKKLAEKSAKSNKDHSKFESNRVDAHGNILLTTLEIHNEVTGNEITTS 386

  Fly   506 TSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRK 570
            .||.|.|..|       .....|......|....|   .||..:|.|
 Frog   387 VSDARNSATS-------FDNSGIQYRKQSTARDSL---GRRTADRNH------------------ 423

  Fly   571 PPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKG 635
            ||:          :|.|                              |||.|..:
 Frog   424 PPK----------KTHL------------------------------RRRSSQLK---------- 438

  Fly   636 KRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLS 672
            .:.|....|:.|||.||||||:.|.|.|:.||..|::
 Frog   439 IKIPDLTDVNAIDRWSRIVFPITFSLFNLIYWLYYIN 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	169/587 (29%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	61/167 (37%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
gabrb3	NP_001096164.1	LIC	11..473	CDD:273305	178/617 (29%)