DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and GLR2.8

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	784	Identity:	139/784 - (17%)
Similarity:	237/784 - (30%)	Gaps:	307/784 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 WSIKEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYLDSDLVRLGVFLDLGCDKA-------- 84
            :.:|....:.|......:.:.|:|    :.|......||      .....|:..|::
plant   152 YQVKAIAAIFESFGWRSVVAIYVD----NELGEGIMPYL------FDALQDVQVDRSVIPSEAND 206

  Fly    85 --------ELVTNQS------SRARLYNQNLHWLLYDEAGNFTKLTQLFEGANLSLNADVTYVSR 135
                    :|:|.|:      ..:||.::     ::::|   |::..:.||....:...:|::.|
plant   207 DQILKELYKLMTRQTRVFVVHMASRLASR-----IFEKA---TEIGMMEEGYVWLMTNGMTHMMR 263

  Fly   136 EDEERFILHDVYNKGSHLGGKLNITVDQTLQCNRSHCQVKEYLSELHLR---------PRLQHRM 191
            .              .|.|..|| |:|..|.. |||....:.|.:..||         |.|  |.
plant   264 H--------------IHHGRSLN-TIDGVLGV-RSHVPKSKGLEDFRLRWKRNFKKENPWL--RD 310

  Fly   192 DLS--------SVTFRLAAL----VSVLPINSSE------------------EELLEFLNSDR-- 224
            |||        |.|....|:    :|..|.|::.                  ..|||.|:..|
plant   311 DLSIFGLWAYDSTTALAMAVEKTNISSFPYNNASGSSNNMTDLGTLHVSRYGPSLLEALSEIRFN 375

  Fly   225 ---------DSHMDS-----ISRIGNRLIMHTQEILGFKL----------------------HYI 253
                     |..::|     |:.:||.     :.|:||..                      ..|
plant   376 GLAGRFNLIDRQLESPKFEIINFVGNE-----ERIVGFWTPSNGLVNVNSNKTTSFTGERFGPLI 435

  Fly   254 WCGT-------WS-------------VQDAFGGAIGMLTNESAELCTTP---------------- 282
            |.|.       |.             |:..|...:.::|:....: |||
plant   436 WPGKSTIVPKGWEIPTNGKKIKVGVPVKKGFFNFVEVITDPITNI-TTPKGYAIDIFEAALKKLP 499

  Fly   283 --FVPSWNRLH------------------------------------YLHPMTEQAQFRAVCMFR 309
              .:|.:.|..                                    :..|.||..   ...|..
plant   500 YSVIPQYYRFESPDDDYDDLVYKVDNGTLDAVVGDVTITAYRSLYADFTLPYTESG---VSMMVP 561

  Fly   310 TPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLWMIFHLERHWMQRCLDF----IPSLLSSCL 370
            ...|......|||:|:...:|...|...:..|.::|:..|...      .||    ...:.:|..
plant   562 VRDNENKNTWVFLKPWGLDLWVTTACFFVLIGFVVWLFEHRVN------TDFRGPPHHQIGTSFW 620

  Fly   371 ISFGAACIQGSYLMPKSAGGRLA--------FIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRT 427
            .||....    :...:.....||        |:.::||.....|..:.:.|...  .|...|::.
plant   621 FSFSTMV----FAHREKVVSNLARFVVVVWCFVVLVLTQSYTANLTSFLTVQRF--QPAAINVKD 679

  Fly   428 IQQLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVE-SKRDPNSVWLSPEE--------GV 483
            :.:..|.   ||:....|.|.:|:           |:... ||..|   :.|.||        .:
plant   680 LIKNGDY---VGYQHGAFVKDFLI-----------KEGFNVSKLKP---FGSSEECHALLSNGSI 727

  Fly   484 IRVRDQPGFV--YTSEASFMYHFVEKHY--------LPRE---ISDLNEIILRPESAVYG--MVH 533
            ....|:..::  ..|:....|..||..:        .||.   ..|:::.||   :...|  |.|
plant   728 SAAFDEVAYLRAILSQYCSKYAIVEPTFKTAGFGFAFPRNSPLTGDVSKAIL---NVTQGDEMQH 789

  Fly   534 LNSTYRQLLTQLQVRMLETGITSKQSRFFSKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLAL 598
            :.:.:  .:.|......:|.::|      ::..|.:|...|:| .|            :|.||||
plant   790 IENKW--FMKQNDCPDPKTALSS------NRLSLRSFWGLFLI-AG------------IASFLAL 833

  Fly   599 LILI 602
            ||.:
plant   834 LIFV 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	46/260 (18%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	58/307 (19%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	62/378 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000