DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and GLR2

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	743	Identity:	148/743 - (19%)
Similarity:	247/743 - (33%)	Gaps:	246/743 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SIKEAFPL-------VEMLNQ----NGIFSQYIDV-----------QNPDNLANVHKEY------ 65
            |.|...||       ||::.:    .|:.|:.|.|           :..:.|..:.|.|
plant   198 SYKAVLPLDVVITSPVEIIEELIKIRGMESRVIVVNTFPNTGKMIFKEAERLGMMEKGYVWIATT 262

  Fly    66 -----LDSDLVRLGVFLDLGCDKAELVTNQSSRAR----------------------LYNQNLHW 103
                 |||:| .|...|..|.....|.|..|.:.|                      ||..:..|
plant   263 WLSSVLDSNL-PLDTKLVNGVLTLRLHTPDSRKKRDFAARWKNKLSNNKTIGLNVYGLYAYDTVW 326

  Fly   104 L-------LYDEAGNFT-----KLTQLFEGANLSLNADVTYVSREDEERFIL-HDVYNKGSHLGG 155
            :       |.:..||.:     ||..| :|..|:|:|    :||.|:...:| :.|:.|.|.|.|
plant   327 IIARAVKTLLEAGGNLSFSNDAKLGSL-KGEALNLSA----LSRFDQGSQLLDYIVHTKMSGLTG 386

  Fly   156 KLNITVDQT----------LQCNRSHCQVKEY--LSELHLRP----------RLQHRMDLSSVTF 198
            .:....|::          |..:|.| |:..:  .|.|.:.|          |......|:|||:
plant   387 PVQFHPDRSMLQPSYDIINLVDDRVH-QIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHLNSVTW 450

  Fly   199 RLAALVSVLP---INSSEEELLEFLNSDRDSHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWSV 260
              ....||.|   |..:....|.....||.|..|.:||:..    .:.::.|:.:
plant   451 --PGGTSVTPRGWIFRNNGRRLRIGVPDRASFKDFVSRVNG----SSNKVQGYCI---------- 499

  Fly   261 QDAFGGAIGM---------------LTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAV----- 305
             |.|..|:.:               |||           |::|.|  ::.:|....|.||
plant   500 -DVFEAAVKLLSYPVPHEFIFFGDGLTN-----------PNYNEL--VNKVTTGVDFDAVVGDIA 550

  Fly   306 --------CMFRTPH-NAGIKAA-----------VFLEPFMPSVWFAFAGLLIFAGVLLWMIFHL 350
                    ..|..|: .:|:...           .||.||...:|...|...:..|..:|::.|.
plant   551 IVTKRTRIVDFTQPYIESGLVVVAPVTRLNENPWAFLRPFTLPMWAVTASFFVIVGAAIWILEHR 615

  Fly   351 --------ERHWMQRCLDFIPSLLSSCLISFGAACIQGSYLMPKSAGGRLAFIAVMLTSFLMYNY 407
                    .|..:...|.|   ..|:...|.....:        |..||:..:..:....::.:.
plant   616 INDEFRGPPRRQIITILWF---TFSTMFFSHRETTV--------STLGRMVLLIWLFVVLIITSS 669

  Fly   408 YTSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDP 472
            ||:.:.|.|....:.|.|:.:..|..|:..:||....|.:.|:.     |..::...::.....|
plant   670 YTASLTSILTVQQLNSPIKGVDTLISSTGRIGFQVGSFAENYMT-----DELNIASSRLVPLASP 729

  Fly   473 NSVWLSPEEG-VIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAV---YGMVH 533
            .....:.:.| |..:.|                 |:.|:...:||..:..:|.:...   :|...
plant   730 EEYANALQNGTVAAIVD-----------------ERPYIDLFLSDYCKFAIRGQEFTRCGWGFAF 777

  Fly   534 LNSTYRQLLTQLQVRML---ETGITSK-QSRFFSKT----------------KLHTFSNSFVIQV 578
            ...:  .|...:...:|   |||...| ..|:.||:                .:|:|...|:: |
plant   778 PRDS--PLAVDMSTAILGLSETGELQKIHDRWLSKSNCSSPHGSQSGDSEQLNVHSFWGMFLV-V 839

  Fly   579 GMEYAAPLFISLLVAYFLALLILILEIC 606
            |        |:.|||.|:....:|.:.|
plant   840 G--------IACLVALFIHFFKIIRDFC 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	39/239 (16%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	52/232 (22%)
		GluR_Plant	468..808	CDD:270404	71/402 (18%)
		Lig_chan	594..843	CDD:306551	51/292 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000