DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and grid1a

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	759	Identity:	150/759 - (19%)
Similarity:	253/759 - (33%)	Gaps:	217/759 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPLYRLIVFNLLEINLSNLMVFHCWSIKEAFPLVEMLNQNGIFSQYIDVQNPD-NLANVHKEYLD 67
            |  ::.|||...|.::..|..|              |:|.......:.:|..| |:..|......
Zfish   162 W--HKFIVFYDSEYDVRGLRGF--------------LDQASRMGLDVSLQQVDRNVTKVFSTLFS 210

  Fly    68 S----------DLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLHW--------------LLYDE 108
            :          |.:|..:.| |....|::..:|:....|.:::.||              |::..
Zfish   211 TMRMEELNRYRDTLRRAILL-LSPRTAQVFIHQAVETNLASKDSHWVYANEEVSDTEIMELVHSA 274

  Fly   109 AGNFTKLTQLF-------------------------EGANLSLNADVTYV-----------SRED 137
            .|..|.:.|:|                         ||...||.....|:           .|:.
Zfish   275 LGRMTVIRQIFPLWRDTNIRCMRNNHRISSLLCDPQEGYLQSLEVSSLYLYDSVLMLANAFYRKL 339

  Fly   138 EER---------------------FILHDVYNKG--SHLGGKLNITVDQTLQCNRSHCQ------ 173
            |:|                     :.:.|...||  |.|.|.::...:..    .||.|
Zfish   340 EDRKWHSMASLNCMRKSTKPWNGGWSMLDTIQKGRISGLTGLMDFRSNGA----NSHVQFEILGT 400

  Fly   174 ---------VKE---YLSELHLRPRL-QHRMD--LSSVTFRLAALVSVLPINSSEEELLEFLNSD 223
                     ||.   :.|:..|...| ::|.|  :..:|.::..|:.. |.....|.:|......
Zfish   401 SYSETFGKDVKRLATWDSDRGLNGSLRENRADHGMQGITLKVVTLLEE-PFVMVAENILGQPKRY 464

  Fly   224 RDSHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWSVQDA----------FGGAIGMLTNESAEL 278
            :...:|.:..:.        :|||||..     .:.|.||          :.|.||.|..:.|::
Zfish   465 KGFSIDVLDALA--------KILGFKYE-----MYQVADAKYGSPQTNGSWNGMIGELIGKRADV 516

  Fly   279 CTTPFVPSWNRLHYLHPMTEQAQFR-AVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGV 342
            ..:....:..|.:.:........:. .:.|.:|.....|.:  .|.||..:||...|..:...||
Zfish   517 AISAITITPERENVVDFSKRYLDYSVGILMTKTEERLNIFS--LLAPFDLAVWACIAAAIPVVGV 579

  Fly   343 LLWMIFHLERHWMQRC---------LDFIPSLLSSCLISFGAACIQGSYLMPKSAGGRLAFIAVM 398
               |:|.|.|....|.         .....|..|:..|.:||...||......|...|:|..:..
Zfish   580 ---MVFLLRRVQSVRSQNPPGPHQPASVTTSFQSAIWIVYGAFVQQGGESFMSSMALRIAMGSWW 641

  Fly   399 LTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTV---PFTKTYLVSSPRP---- 456
            |.:.::.:.||:.:.:.|..|.:.:.|||.|.|:..| ::.:.||   ...:.:.|....|
Zfish   642 LFTLIVCSSYTANLAAYLTVSRMDNAIRTFQDLSKQS-EINYGTVRESAVFEYFRVKGTNPLEQD 705

  Fly   457 -DIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEI 520
             ....|::...:::...||| .||.||:.:|:..|       .:|::......|......|...:
Zfish   706 STFAELWRTINKNQGQDNSV-TSPAEGIRKVKRDP-------YAFLWDMAVLEYAALTDDDCTLV 762

  Fly   521 IL--RPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITS--KQSRFFSK---------------- 564
            :.  ...|..||: :...|.||.|.:|..:.:.|.|...  ||..:..|
Zfish   763 VTGNGMSSKGYGLALQHGSPYRDLFSQKILDLQEKGDLDILKQKWWPRKGRCDLDKHAEPQTEGR 827

  Fly   565 -TKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW 607
             .:||:|:..|.|             |.....||.|:..||..|
Zfish   828 ALRLHSFAGVFCI-------------LAAGLLLACLVAALESWW 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	57/244 (23%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	48/282 (17%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	86/399 (22%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740