DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and Grid2

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	132/708 - (18%)
Similarity:	261/708 - (36%)	Gaps:	188/708 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIVFN-------LLEINLSNLMVFHC-W------------------------SIKEAFPLVEMLN 41
            ::|.|       :.|:..:||:.|.| |                        .|::.||:.:.::
  Rat   231 ILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNIS 295

  Fly    42 QNGI----------------FSQYIDVQN---PDN---LANV-HKEYLDSDLVRLGVFLDLGCDK 83
            |...                |:|.:::.|   .|.   |||. ||:..|.   :......|.|.:
  Rat   296 QRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDR---KWHSMASLSCIR 357

  Fly    84 AELVTNQSSRARLYNQNLHWLLYDEAGNFTKLTQLFE----GANLSLNADVTYVSREDEERFILH 144
            ......|..|:.|..        .:.|....||...|    |.|.:::.::.
  Rat   358 KNSKPWQGGRSMLET--------IKKGGVNGLTGDLEFGENGGNPNVHFEIL------------- 401

  Fly   145 DVYNKGSHLGGKLNITVDQTLQCNRSHCQVKEYLSELHLRPRLQHRMDLSSVTFRLAALVSVL-- 207
                 |::.|.:|...| :.|.|......:...|::    .:|::.|  ..|..|   :|:||
  Rat   402 -----GTNYGEELGRGV-RKLGCWNPVTGLNGSLTD----KKLENNM--RGVVLR---VVTVLEE 451

  Fly   208 PINSSEEELLEFLNSDRDSHMDSISRIGNRLIMHTQEILGFKLHYIWC------------GTWSV 260
            |.....|.:|......:...:|.:..:.|        .|||. :.|:.            |||:
  Rat   452 PFVMVSENVLGKPKKYQGFSIDVLDALSN--------YLGFN-YEIYVAPDHKYGSPQEDGTWN- 506

  Fly   261 QDAFGGAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPF 325
                 |.:|.|..:.|::..:....:.:|.:.:...|....:....:.|..... :.....|.||
  Rat   507 -----GLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKT-VDMFACLAPF 565

  Fly   326 MPSVWFAFAGLLIFAGVLLWMIFHLERHWMQRCLDFIPSLLSSCLISFGAACIQGSYLMPKSAGG 390
            ..|:|...||.::..|:|::::..|....:|.......:|.:|....:|:...||..:...:...
  Rat   566 DLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLAT 630

  Fly   391 RLAFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTV------------ 443
            |:...|..|.:.::.:.||:.:.:.|..:.:.|:|:::|.|:..: |:.:.||
  Rat   631 RMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQT-DIPYGTVLDSAVYQHVRMK 694

  Fly   444 ---PFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFV 505
               ||.:..:.|       .:::....|....|:| |..:.|:.:|:      |.:.| |::...
  Rat   695 GLNPFERDSMYS-------QMWRMINRSNGSENNV-LESQAGIQKVK------YGNYA-FVWDAA 744

  Fly   506 EKHYLPREISDLNEIILRPESAVY-------------GMVHLNSTYRQLLTQLQVRMLETG-ITS 556
            ...|:  .|:|       |:.:.|             .:.| .|.||.:.:|..:.:.::| :..
  Rat   745 VLEYV--AIND-------PDCSFYTVGNTVADRGYGIALQH-GSPYRDVFSQRILELQQSGDMDI 799

  Fly   557 KQSRFFSKT-KLHTFSNSFVIQVG----MEYAAPLFISLLVAYFLALLILILEICWAR 609
            .:.:::.|. :...:|:....|.|    ::..|.:|..|.....|:.||.:||..|:|
  Rat   800 LKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	48/252 (19%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		21/113 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	39/227 (17%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	76/410 (19%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349814
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740