DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and grik4

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	588	Identity:	123/588 - (20%)
Similarity:	223/588 - (37%)	Gaps:	112/588 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 CDKAELVTNQSSRARLYNQNLHWLL-----YDEAGNF------TKLTQLFEGANLSLNADVTYVS 134
            ||.|.......|.|.|::. :|.::     .:.:.|.      .|.::::|.....:|    |:.
Zfish   293 CDHAPFAGTPLSSALLFDA-VHTVVAAVQELNRSQNVGATQLSCKSSKIWEHGTSLMN----YLR 352

  Fly   135 REDEERFILHDVYN-KGSHLGGKLNITVDQTLQCNRSHC-QVKEYLSELHLR-----PRLQHRMD 192
            ..:.|....|..:| ||......|.|     :|.:|... |:.::.||..|.     |.|.....
Zfish   353 MVELEGLTGHIEFNSKGQRSNYALRI-----MQNSRDGLRQIGQWHSEQGLSMERKLPSLNVTDT 412

  Fly   193 LSSVTFRLAALVS----VLPINSSEEELLEFLNSDRDSH--MDSISRIGNRLIMHTQEILGFK-- 249
            |.:.|..:..::.    :|..|..|.|     .:||...  :|.:..:.        :||.||
Zfish   413 LFNTTLTITTILENPYVMLRANHQELE-----GNDRYEGFCVDMLKELA--------DILKFKYR 464

  Fly   250 LHYIWCGTWSVQDAFG---GAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTP 311
            :..:..|.:.|..|.|   |.:|.|.:..|:|...             .:|..|:...|..|..|
Zfish   465 IRLVGDGVYGVPGANGTWTGMVGELISRKADLAVA-------------ALTITAEREKVIDFSKP 516

  Fly   312 H-NAGIKAAV------------FLEPFMPSVWFAFAGLLIFAGVLLWMIFHLERH-WMQ------ 356
            . ..||....            ||:||.|.||.......:....:|:::..|..: |..
Zfish   517 FMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYNPHPCLK 581

  Fly   357 -RCLDFIP--SLLSSCLISFGAACIQGSYLMPKSAGGRL------AFIAVMLTSFLMYNYYTSIV 412
             ||...|.  ||.:|.....|....|||.:.|::...|.      ||..::::|      ||:.:
Zfish   582 GRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISS------YTANL 640

  Fly   413 VSTLLGSPVRSNIRTIQQLAD-SSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVW 476
            .:.|....:...|.::..||| ::::.|......|.|:..:|.....:.::  .....:.|:...
Zfish   641 AAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSRYQTYQRMW--NFMYSKQPSVFV 703

  Fly   477 LSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQ 540
            .|.|||:.||.:. .:.|..|::     :.::|..|. .:|.:|....::..||: :.|.|.||.
Zfish   704 KSTEEGIARVLNS-NYAYLLEST-----MNEYYRQRN-CNLTQIGGLLDTKGYGIGMPLGSVYRD 761

  Fly   541 LLTQLQVRMLETG-ITSKQSRFFSKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILE 604
            ......:|:.|.. :...:.:::...|.....:.....:|||....:|:.|:....:|:.:.:||
Zfish   762 EFDLAILRLQEENRLEILKRKWWDGGKCPKEEDHRAKGLGMENIGGIFVVLVCGLLVAIFMAVLE 826

  Fly   605 ICW 607
            ..|
Zfish   827 FVW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	52/242 (21%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	25/116 (22%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	84/400 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840