DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and grik2

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	575	Identity:	125/575 - (21%)
Similarity:	208/575 - (36%)	Gaps:	145/575 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 HWLLYDEAGNFTKLTQLFEGANLSLNADVTYVSREDEERFILHDVYNKGSHLGGKLNITVDQTLQ 166
            ||.......||.:.    .|.....:.||..:..|..|:....|.       ...||:|.:|
Zfish   367 HWDGLTGRINFNRT----NGLRTDFDLDVISLKEEGLEKIGTWDP-------ASGLNMTENQ--- 417

  Fly   167 CNRSHCQVKEYLSELHLRPRLQHRMDLSSVTFRLAALVSVLPINSSEEELLEFLNSDRDSHMDSI 231
             ......|.:.||...|                   :||.:    .||..:.|..||:..:
Zfish   418 -KGKTANVTDSLSNRSL-------------------VVSTI----LEEPYVMFKKSDKPLY---- 454

  Fly   232 SRIGN--------RLIMHTQEILGF--KLHYIWCGTWSVQD----AFGGAIGMLTNESAELCTTP 282
               ||        .|:.....||||  :|..:..|.:..||    .:.|.:..|.:..|:|...|
Zfish   455 ---GNDRFEGYCVDLLRELAAILGFGYELRLVEDGRYGAQDESSGQWNGMVRELMDHKADLAVAP 516

  Fly   283 FVPSWNR---LHYLHP-MTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGV- 342
            ...::.|   :.:..| ||    .....::|.|:........||.|..|.:|...  ||.:.||
Zfish   517 LAITYVREKVIDFSKPFMT----LGISILYRKPNGTNPGVFSFLNPLSPDIWMYI--LLAYLGVS 575

  Fly   343 -LLWMIFHLERH-WM--QRC---LDFIP---SLLSSCLISFGAACIQGSYLMPKSAGGRLA---- 393
             :|::|.....: |.  ..|   .|.:.   :||:|.....||...|||.||||:...|:.
Zfish   576 CVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIW 640

  Fly   394 --FIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLA-DSSLDVGF----DTVPFTKTYLV 451
              |..::::|      ||:.:.:.|....:.|.|.:...|| .:.::.|.    .|:.|.|...:
Zfish   641 WFFTLIIISS------YTANLAAFLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKI 699

  Fly   452 SSPRPDIRSLYKQKVE--SKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREI 514
            |:        |.:..|  |.|..:.:..|.|||:.|       |.||:.:|:.......::.:..
Zfish   700 ST--------YDKMWEFMSSRRHSVMVKSIEEGIER-------VLTSDYAFLMESTTIEFVTQRN 749

  Fly   515 SDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSKQSRFFSKTKLHTF-------- 570
            .:|.:|....:|..||: ..:.|.||..:|...:::.|.|            |||..
Zfish   750 CNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEG------------KLHMMKEKWWRGN 802

  Fly   571 -----SNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW-----ARYAKKKF 615
                 .|.....:|::....:||.|.....|::.:.:.|..:     |:..|:.|
Zfish   803 GCPEEENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKQNAQLEKRSF 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	60/249 (24%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	12/57 (21%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	98/438 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840