Protein Alignment Ir75c and Grik2

DIOPT Version :10

• Sequence 1: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_062182.1
• Gene: Grik2 / 54257
• RGDID: 2733
• Length: 908
• Species: Rattus norvegicus
• Alignment Length: 730
• Identity: 143/730 - (19%)
• Similarity: 250/730 - (34%)
• Gaps: 226/730 - (30%)

  Fly    31 KEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYLDSDLVRLGVFLDLGCDKAELVTNQSSRAR 95
            |:|.||::.:.:.                   ||:        .|..|...:.|..:..|:....
  Rat   209 KDAKPLLKEMKRG-------------------KEF--------HVIFDCSHEMAAGILKQALAMG 246

  Fly    96 LYNQNLHWLLYDEAGNFTKLTQL--------FEGANLS----LNADVTYVSREDE----ERF--- 141
            :..:..|::       ||.|...        :.|.|::    ||.:.|.||...|    ||.
  Rat   247 MMTEYYHYI-------FTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304

  Fly   142 -----------------ILHDVYNKGSHLGGKLNITVDQ-------TLQCNRSH-----CQVKEY 177
                             :::|..    |:   :::.|.|       :|||||..     .:....
  Rat   305 PKPDSGLLDGFMTTDAALMYDAV----HV---VSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSL 362

  Fly   178 LSELH---LRPR--------LQHRMDLSSVTFRLAALVSV-----------------LPINSS-- 212
            :.|.|   |..|        |:...||..::.:...|..:                 .|.|.:
  Rat   363 IKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDS 427

  Fly   213 ------------EEELLEFLNSDRDSHMDSISRIGN--------RLIMHTQEILGF--KLHYIWC 255
                        ||..:.|..||:..:       ||        .|:.....||||  ::..:..
  Rat   428 LSNRSLIVTTILEEPYVLFKKSDKPLY-------GNDRFEGYCIDLLRELSTILGFTYEIRLVED 485

  Fly   256 GTWSVQD----AFGGAIGMLTNESAELCTTPFVPSWNR---LHYLHP-MTEQAQFRAVCMFRTPH 312
            |.:..||    .:.|.:..|.:..|:|...|...::.|   :.:..| ||    .....::|.|:
  Rat   486 GKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMT----LGISILYRKPN 546

  Fly   313 NAGIKAAVFLEPFMPSVWFAFAGLLIFAGV--LLWMIFHLERH-WM--QRC---LDFIP---SLL 366
            ........||.|..|.:|...  ||...||  :|::|.....: |.  ..|   .|.:.   :||
  Rat   547 GTNPGVFSFLNPLSPDIWMYV--LLACLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLL 609

  Fly   367 SSCLISFGAACIQGSYLMPKSAGGRLA------FIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNI 425
            :|.....||...|||.||||:...|:.      |..::::|      ||:.:.:.|....:.|.|
  Rat   610 NSFWFGVGALMRQGSELMPKALSTRIVGGIWWFFTLIIISS------YTANLAAFLTVERMESPI 668

  Fly   426 RTIQQLA-DSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQ 489
            .:...|| .:.::.|......|.|:...|.......::  ...|.|..:.:..|.|||:.|
  Rat   669 DSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW--AFMSSRRQSVLVKSNEEGIQR---- 727

  Fly   490 PGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETG 553
               |.||:.:|:.......::.:...:|.:|....:|..||: ..:.|.||..:|...:::.|.|
  Rat   728 ---VLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEG 789

  Fly   554 ITSKQSRFFSKTKLHTFSNSF-------------VIQVGMEYAAPLFISLLVAYFLALLILILEI 605
                        |||.....:             ...:|::....:||.|.....|::.:.:.|.
  Rat   790 ------------KLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEF 842

  Fly   606 CW-----ARYAKKKF 615
            .:     |:..|:.|
  Rat   843 LYKSKKNAQLEKRSF 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	47/197 (24%)
Grik2	NP_062182.1	PBP1_iGluR_Kainate	37..414	CDD:380605	41/245 (17%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	91/409 (22%)