DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and grin2da

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	466	Identity:	88/466 - (18%)
Similarity:	163/466 - (34%)	Gaps:	125/466 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 LPINSS--EEELLEFLNSDRDSHMDSISRIGNRLIMHTQEILGF--KLHYIWCGTW--SVQDAFG 265
            ||:|:|  .|.:....:..:...:|.:.|:.        :|:||  .|:.:..|..  ::...:.
Zfish   487 LPLNNSMVVEGIQSMKHCCKGFCIDVLKRLA--------KIVGFTYDLYLVTNGRHGKNIDGQWN 543

  Fly   266 GAIGMLTNESAELCTTPFVPSWNR---LHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMP 327
            |.:|.:.::.|::.......:..|   :.:..|..|    ..:.:..:..|..:..:.||||:.|
Zfish   544 GMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVE----TGISVMVSRSNGTVSPSAFLEPYSP 604

  Fly   328 SVWFAFAGLLIFAGVLLWMIFHLERHWMQRCLDFIPSLLSSCLISFGAACIQGSYLMPKSAGG-- 390
            :||.....:.:....:...||..          |.|       :.:..:...|     |:|||
Zfish   605 AVWVMMFVMCLSVVAVTVFIFEF----------FSP-------VGYNRSLQSG-----KTAGGSK 647

  Fly   391 -----------RLAF---------------IAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQ 429
                       .|.|               |.|::.:|....:..|...:..........|.|:.
Zfish   648 FTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVS 712

  Fly   430 QLADSSLD--------VGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRV 486
            .|:|....        :.|.|||      ..|...:|||.|         ||............|
Zfish   713 GLSDKKFQHPTEQYPPLRFGTVP------NGSTEENIRSNY---------PNMHQYMVRNNQRGV 762

  Fly   487 RDQPGFVYTSEA-SFMYHFVEKHYLPREISDLNEIILRP----ESAVYGM-VHLNSTYR------ 539
            .|....:.|.:. :|:|.....:|:.|:......:.:..    .:..||: :|.||.::
Zfish   763 EDAIENLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHKNSRWKRPLDLA 827

  Fly   540 --QLLTQLQVRMLE----TGITSKQSRFFSKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLAL 598
              ||:...::.|||    :||....       |:...|:    ::.::..|.:|..||||..|:|
Zfish   828 LLQLVGDDEIDMLERLWLSGICHND-------KIEVMSS----KLDIDNMAGVFYMLLVAMGLSL 881

  Fly   599 LILILE--ICW 607
            |:...|  :.|
Zfish   882 LVFAWEHLVYW 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	49/278 (18%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	75/412 (18%)
		HisJ	<507..>590	CDD:223904	13/94 (14%)
		Lig_chan	605..877	CDD:278489	58/319 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830