DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and grid2

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	728	Identity:	134/728 - (18%)
Similarity:	253/728 - (34%)	Gaps:	221/728 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LYRLIVFN--------LLEINLSNLMVFHC-WSI------------------------KEAFPLV 37
            |.|.::|.        :.|:..:||:.|.| |.|                        ::.|||.
Zfish   227 LRRAVLFMSPATAKAFITEVVETNLVAFDCQWIIINEEISDMDVQELVMKSIGRLTLVRQTFPLP 291

  Fly    38 E------MLNQNGIFSQYIDVQNPD-NLANVHKEYL-DSDLVRLGVF------------LDLGCD 82
            :      :.|.:.|.:...|.::|. .:..:...|: |:.|:....|            ..|.|.
Zfish   292 QNTSQRCVRNNHRINTSLCDPKDPKAQMLEITNRYIYDTVLLLANTFHRKLEDRKWHSMASLSCI 356

  Fly    83 KAELVTNQSSRARLYNQNLHWLLYDEAGNFTKLTQLFE----GANLSLNADVTYVS-REDEERFI 142
            :......|..::.|...        :.|..:.||.|.|    |:|.:::.::...: .||..|.:
Zfish   357 RKGSKPWQGGKSMLETV--------KKGGVSGLTSLLEFNDNGSNPNIHFEILGTNYGEDRGRGV 413

  Fly   143 --------LHDVYNKGSHLGGKLNITVDQTLQCNRSHCQVKEYLSELHLRPRLQHRMDLSSVTFR 199
                    :|.       |.|.|   .|:.|:.|                        :..|..|
Zfish   414 SRLATWDPIHG-------LNGTL---TDRKLENN------------------------MRGVVLR 444

  Fly   200 LAALVSVL--PINSSEEELLEFLNSDRDSHMDSISRIGNRLIMHTQEILGFKLHYIWC------- 255
               :|:||  |.....|.:|......:...:|.:..:.|        .|||| :.|:.
Zfish   445 ---VVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALAN--------YLGFK-YEIYVAPDHKYG 497

  Fly   256 -----GTWSVQDAFGGAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAG 315
                 |||:      |.||.|..:.|::..:....:..|...:...|....:....:.|.....
Zfish   498 SQQADGTWN------GLIGELVFKRADVGLSALTITPERESVVDFTTRYMDYSVGVLLRKAERT- 555

  Fly   316 IKAAVFLEPFMPSVWFAFAGLLIFAGVLLWMIFHLERHWMQRCLDFIP-------SLLSSCLISF 373
            :.....|.||..|:|...||.::..|.|::::     :|:..  ..:|       :|.:|....:
Zfish   556 VDMFACLAPFDLSLWACIAGTVLLVGTLVYLL-----NWLNP--PRLPMGSVSSTTLYNSMWFVY 613

  Fly   374 GAACIQGSYLMPKSAGGRLAFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDV 438
            |:...||..:...:...|:......|.:.::.:.||:.:.:.|..|.:.::|:::|.||..: |:
Zfish   614 GSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQDLAKQT-DL 677

  Fly   439 GFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDP--NSVWL-------------SPEEGVIRVRD 488
            .:.||      |.|:....:||  |.....:|||  :.:|.             ..:||:.:|:
Zfish   678 PYGTV------LDSAVYDQVRS--KGMNPFERDPMYSQMWRMINRTGGAENNVEESKEGIRKVK- 733

  Fly   489 QPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLET 552
            ...|.:..:|:.:.:..    :..|...|..:........||| :...|.||.:.:|..:.:.:.
Zfish   734 YGRFAFVWDAAVLEYVA----INDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFSQRILELQQN 794

  Fly   553 G---------------------ITSKQSRFFSKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFL 596
            |                     :.:::|.  |...:|:|             |.:|..|.....|
Zfish   795 GDMDILKLKWWPRDSPCDLYSPVGTRKSG--SALDIHSF-------------AGVFFVLAAGVVL 844

  Fly   597 ALLILILEICWAR 609
            :.||..:|..|.|
Zfish   845 SCLIATVETWWTR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	49/247 (20%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	37/214 (17%)
		ANF_receptor	42..404	CDD:279440	32/184 (17%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	79/405 (20%)
		Lig_chan	568..841	CDD:278489	57/308 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740