Protein Alignment Ir75c and GluRIA

DIOPT Version :10

• Sequence 1: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Alignment Length: 667
• Identity: 125/667 - (18%)
• Similarity: 244/667 - (36%)
• Gaps: 182/667 - (27%)

  Fly    34 FPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYLDSDLVRLGVFLDLGCDKAELV-TNQSSRARLY 97
            |.|||..|:       |..:.||...:.|.:.....          |...:... ||:||.....
  Fly   337 FVLVEAFNR-------ILRKKPDQFRSNHLQRRSHG----------GSSSSSATGTNESSALLDC 384

  Fly    98 NQNLHWLLYDEAGNFTKLTQLFEGANL-SLNADVTYVSREDEER--FILHDVYNKGSHLGGKLNI 159
            |.:..|:...|.|.  |::::.....: .|:.::.:  .||..|  :.||.|           .:
  Fly   385 NTSKGWVTPWEQGE--KISRVLRKVEIDGLSGEIRF--DEDGRRINYTLHVV-----------EM 434

  Fly   160 TVDQTLQCNRSHCQVKEYLSELHLRPRLQHRMDLSSVTFRLAA------------LVSVLPINSS 212
            :|:.|||      ||.|:..:..|.|...|....||   |.|:            :||
  Fly   435 SVNSTLQ------QVAEWRDDAGLLPLHSHNYASSS---RSASASTGDYDRNHTYIVS------- 483

  Fly   213 EEELLE--FLNSDRDSHMDSISRIGN-RLIMHTQEI-------LGFK--LHYIWCGTWSVQDAFG 265
              .|||  :|:..:.::.:|:  :|| |...:.:::       ||.|  :..:..|.:..::.:.
  Fly   484 --SLLEEPYLSLKQYTYGESL--VGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYA 544

  Fly   266 -----GAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPH-NAGIKAAV---- 320
                 |.:|.|..:.|::.             :..||..|:...|..|..|. ..||...:
  Fly   545 PGGWDGMVGELIRKEADIA-------------ISAMTITAERERVIDFSKPFMTLGISIMIKKPV 596

  Fly   321 --------FLEPFMPSVWFAFAGLLIFAGVLLWMIFHLER----HWM------------------ 355
                    ||.|....:|.:.  :|.:.|| .::::.:.|    .|.
  Fly   597 KQTPGVFSFLNPLSQEIWISV--ILSYVGV-SFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGII 658

  Fly   356 --------QRCLDFIP----SLLSSCLISFGAACIQGSYLMPKSAGGRLAFIAVMLTSFLMYNYY 408
                    |..:..:|    ::|:|...|..|...||..:.|.|..||:|.......:.::.:.|
  Fly   659 GGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSY 723

  Fly   409 TSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPN 473
            |:.:.:.|....:.:.|:|.:.|. ...||.:.|:.:..|:          ..:::......  |
  Fly   724 TANLAAFLTVERMVAPIKTPEDLT-MQTDVNYGTLLYGSTW----------EFFRRSQIGLH--N 775

  Fly   474 SVW-----------LSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYL-PREISDLNEIILRPES 526
            .:|           .:.:||:.|||...|     :.:.:....:..|: .|...|..::....::
  Fly   776 KMWEYMNANQHHSVHTYDEGIRRVRQSKG-----KYALLVESPKNEYVNARPPCDTMKVGRNIDT 835

  Fly   527 AVYGM-VHLNSTYRQLLTQLQVRMLETG--ITSKQSRFFSKTKLH-TFSNSFVIQVGMEYAAPLF 587
            ..:|: ..:.|..|:.|.:..:.:.|.|  :..:...:|.||:.: ....|...::.:...|.::
  Fly   836 KGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIY 900

  Fly   588 ISLLVAYFLALLILILE 604
            ..|:....||:::.|:|
  Fly   901 YILIGGLLLAVIVAIME 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	37/224 (17%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	35/156 (22%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	78/446 (17%)
		Lig_chan	610..906	CDD:459656	52/316 (16%)