DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and Ir64a

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	788	Identity:	155/788 - (19%)
Similarity:	272/788 - (34%)	Gaps:	239/788 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FPLVEMLNQNGIFSQYI--DV--QNP-------------------DNLANVHKEYLDS----DLV 71
            |.|::.|.::.:|.:.:  ||  |:|                   .:.|..:.|:|:.    :.:
  Fly    88 FQLIKSLYESELFVRIVLLDVLAQSPTSGRPNRPGNGPTGGFSQTPSQAQSNSEWLEGVLRMEAL 152

  Fly    72 RLGVFLDLGCDKA-----ELVTNQSSRARLYNQNLHWLLYDEAG--------------------- 110
            |....:||.|...     ||    :|...||::..||||.::..
  Fly   153 RQIAVVDLACGAVSRRFLEL----ASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSGKRDDGEMEE 213

  Fly   111 --------------NFTKLTQLFEGANLSLNADVTYVSREDE-ERFILHDVYNKGSHLGGKLNIT 160
                          :...:.....|.||.:|.::|...|..| ..:.|.||:|.|.:.||.:|:|
  Fly   214 EEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLT 278

  Fly   161 VDQTLQCNRSHCQVKEYLS----ELHLRPR----LQHRMDLSSVTFRLAALVSVLPINSSEEELL 217
                        ::..:..    :||...|    ::.|||:.....|...:|:...:..:   |:
  Fly   279 ------------EIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGT---LM 328

  Fly   218 EFLNSDRDSHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWSV--QDAFGGAIGMLTNESAELCT 280
            .:|......|:|:::|....|:|..:::..:........:|..  ...|.|.||.|.....::..
  Fly   329 YYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVKNGRFDGMIGALIRNETDIGG 393

  Fly   281 TPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLW 345
            .|......|..::.........|...:||.|.:......|||:||...||....|..:....:||
  Fly   394 APIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILW 458

  Fly   346 MIFHLE--------------------RH------------------------------------- 353
            .:..:|                    ||
  Fly   459 FLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEY 523

  Fly   354 -----------WMQRCL------------------DFIPSLLSSCLISFGAACIQGSYLMPKSAG 389
                       | |||.                  :.:...|.|.|...|..|.||.........
  Fly   524 EDSTPIDAGTLW-QRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVS 587

  Fly   390 GRLAFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTVPFTKTYLVSSP 454
            ||...|..:|.||.:|.:|::.:|.|||....:: |:|:..|..|||.||.:.:.:.:.|.:.:.
  Fly   588 GRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKT-IKTLSDLVHSSLKVGMEDILYNRDYFLHTK 651

  Fly   455 RPDIRSLYKQKVES-------------KRDPNSV----------------------------WLS 478
            .|....||.:|:.|             ..|||.|                            ||.
  Fly   652 DPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLD 716

  Fly   479 PEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGMVHLNSTYRQLLT 543
            ||.|::|   ..||.:..:.:..|..:.:.:..::|.||.|:.:.|......::..||..|::::
  Fly   717 PETGLLR---HLGFAFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSIMQKNSPMRKVIS 778

  Fly   544 QLQVRMLETGITSKQSRFFSK------TKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILI 602
            ....|:.||||.:.....:..      .|:.|..    :.|.|:..:...:.||.:|.:.|:||.
  Fly   779 YGLRRVTETGILTYHFNVWHSRKPPCVKKIETSD----LHVDMDTVSSALLILLFSYAITLMILG 839

  Fly   603 LEICWARY 610
            .||.::::
  Fly   840 TEILYSKW 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	68/351 (19%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	23/113 (20%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	63/272 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462750
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191034at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850