DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and Grik3

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	102/470 - (21%)
Similarity:	170/470 - (36%)	Gaps:	111/470 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 SVTFRLAALVSVLPINSSEEELLEFLNSDRDSHMDSISRIGN--------RLIMHTQEILGF--K 249
            |:|.|...:.::|     ||..:.|..|||..:       ||        .|:.....||||  :
  Rat   430 SLTNRSLIVTTLL-----EEPFVMFRKSDRTLY-------GNDRFEGYCIDLLKELAHILGFSYE 482

  Fly   250 LHYIWCGTWSVQDAFG---GAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCM---- 307
            :..:..|.:..||..|   |.:..|.:..|:|...|       |...|...:...|....|
  Rat   483 IRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAP-------LTITHVREKAIDFSKPFMTLGV 540

  Fly   308 ---FRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLWMIFHLERHWMQRCLDFIP------ 363
               :|.|:........||.|..|.:|...  ||.:.||.. ::|.:.|.......|..|
  Rat   541 SILYRKPNGTNPSVFSFLNPLSPDIWMYV--LLAYLGVSC-VLFVIARFSPYEWYDAHPCNPGSE 602

  Fly   364 ------SLLSSCLISFGAACIQGSYLMPKSAGGRLA------FIAVMLTSFLMYNYYTSIVVSTL 416
                  :||:|.....|:...|||.||||:...|:.      |..::::|      ||:.:.:.|
  Rat   603 VVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISS------YTANLAAFL 661

  Fly   417 LGSPVRSNIRTIQQLA-DSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPE 480
            ....:.|.|.:...|| .:.::.|......|.|:...|   .|.:..|........|:::..:.|
  Rat   662 TVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKS---KISTFEKMWAFMSSKPSALVKNNE 723

  Fly   481 EGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLT- 543
            ||:.|       ..|::.:.:.......|:.:...:|.:|....:|..||: ..:.|.||..:|
  Rat   724 EGIQR-------TLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITI 781

  Fly   544 ---QLQVRMLETGITSKQSRFFSKTKLHTF-------------SNSFVIQVGMEYAAPLFISLLV 592
               |||                .:.|||..             .|.....:|::....:||.|..
  Rat   782 AILQLQ----------------EEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAA 830

  Fly   593 AYFLALLILILEICW 607
            ...|::|:.:.|..:
  Rat   831 GLVLSVLVAVGEFIY 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	55/248 (22%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388
		ANF_receptor	55..398	CDD:279440
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	92/421 (22%)
		Lig_chan	564..832	CDD:278489	63/302 (21%)
		Glutamate binding	690..692		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740