back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and Gria3

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001106213.1	Gene:	Gria3 / 29628	RGDID:	70958	Length:	888	Species:	Rattus norvegicus

Alignment Length:	668	Identity:	132/668 - (19%)
Similarity:	243/668 - (36%)	Gaps:	117/668 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YRLIVFNLLEINLSNLMVFHCWSIKEAFPLVEMLNQNGIFSQYI------DVQNPDNLANVHKEY 65
            |.|......:|.|..:|  |..:....|.:|.  |:|.:..|:|      |.:......|...:|
  Rat   239 YMLANLGFTDILLERVM--HGGANITGFQIVN--NENPMVQQFIQRWVRLDEREFPEAKNAPLKY 299

  Fly    66 L-----DSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLHWLLYDEAGNFTKLTQLFEGANLS 125
            .     |:.||....|..|...:.::....|:...|.|..:.|....:.....|:.|: :|...:
  Rat   300 TSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQV-QGMTGN 363

  Fly   126 LNADVTYVSREDEERFILHDVYN---KGSHLGGKLNITVDQTLQCNRSHCQVKEYLSELHLRPRL 187
            :..| ||..|.:    ...|||.   .||...|..|                 ||...:....:
  Rat   364 IQFD-TYGRRTN----YTIDVYEMKVSGSRKAGYWN-----------------EYERFVPFSDQ- 405

  Fly   188 QHRMDLSSVTFRLAALVSVLP----INSSEEELLEFLNSDRDSHMDSISRIGNRLIMHTQEILGF 248
            |...|.||...|...:.::|.    :.....|.||    ..:.:......:...:..|.:  :.:
  Rat   406 QISNDSSSSENRTIVVTTILESPYVMYKKNHEQLE----GNERYEGYCVDLAYEIAKHVR--IKY 464

  Fly   249 KLHYIWCGTWSVQD----AFGGAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFR 309
            ||..:..|.:..:|    .:.|.:|.|....|::...|...:..|...:.............|.:
  Rat   465 KLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIK 529

  Fly   310 TPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLWMI-------FHLERHWMQRCLDFIP---- 363
            .|..:......||:|....:|.......|...|:|:::       :|||.:..:......|
  Rat   530 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP 594

  Fly   364 ---SLLSSCLISFGAACIQGSYLMPKSAGGRLA-----FIAVMLTSFLMYNYYTSIVVSTLLGSP 420
               .:.:|...|.||...||..:.|:|..||:.     |..:::.|....|....:.|..:: ||
  Rat   595 NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SP 658

  Fly   421 VRS--NIRTIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQ--KVESKRDPNSVWLSPEE 481
            :.|  ::....::|..:||.|.....|.::.:         ::|::  ......:|:....:..:
  Rat   659 IESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI---------AVYEKMWSYMKSAEPSVFTKTTAD 714

  Fly   482 GVIRVRDQPG-FVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQ 544
            ||.|||...| |.:..| |.|..::|:    |:..|..::....:|..||: ....|.....:..
  Rat   715 GVARVRKSKGKFAFLLE-STMNEYIEQ----RKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNL 774

  Fly   545 LQVRMLETGITSK-QSRFF------------SKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFL 596
            ..:::.|.|:..| :::::            ||.|....|.|.|        |.:|..|:....|
  Rat   775 AVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNV--------AGVFYILVGGLGL 831

  Fly   597 ALLILILEICWARYAKKK 614
            |:::.::|.|:...|:.|
  Rat   832 AMMVALIEFCYKSRAESK 849

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.