Protein Alignment Ir75c and GRIK5

DIOPT Version :10

• Sequence 1: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 104/476 - (21%)
• Similarity: 180/476 - (37%)
• Gaps: 109/476 - (22%)

  Fly   200 LAALVSVLPINSSE---------EELLEFLNSDRDSHMDSISRIGNR--------LIMHTQEILG 247
            ||...:.|.||.|:         ..:||.....|..:..::|  ||.        ::....|:|.
Human   397 LAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALS--GNERFEGFCVDMLRELAELLR 459

  Fly   248 F--KLHYIWCGTWSVQDAFG---GAIGMLTN-ESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVC 306
            |  :|..:..|.:...:..|   |.:|.|.| :.|:|....|             |..|:...|.
Human   460 FRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAF-------------TITAEREKVI 511

  Fly   307 MFRTPH-----------NAGIKAAV--FLEPFMPSVWFAFAGLLIFAGVLLWMIFHLERH-WM-- 355
            .|..|.           :.|.|...  ||:||.|:||.......:....:|::...|..: |.
Human   512 DFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNP 576

  Fly   356 QRCLDFIPSLL-------SSCLISFGAACIQGSYLMPKSAGGRL------AFIAVMLTSFLMYNY 407
            ..||...|.:|       :|.....|....|||.:||::...|.      ||..::::|
Human   577 HPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISS------ 635

  Fly   408 YTSIVVSTLLGSPVRSNIRTIQQLAD-SSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRD 471
            ||:.:.:.|....:...:.:...||| ::::.|......|.|:..:|.....:.::.. ::||:
Human   636 YTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNY-MQSKQ- 698

  Fly   472 PNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLN 535
            |:....|.|||:.|       |..|..:|:.......|..|...:|.:|....::..||: :.|.
Human   699 PSVFVKSTEEGIAR-------VLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLG 756

  Fly   536 STYRQLLT----QLQV---------RMLETGITSKQSRFFSKTKLHTFSNSFVIQVGMEYAAPLF 587
            |.:|..:|    |||.         :..|.|...|:....:|            .:|||....:|
Human   757 SPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAK------------GLGMENIGGIF 809

  Fly   588 ISLLVAYFLALLILILEICWA 608
            |.|:....:|:.:.::|..|:
Human   810 IVLICGLIIAVFVAVMEFIWS 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	41/196 (21%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	2/3 (67%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	85/400 (21%)