DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and GRIK4

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	693	Identity:	134/693 - (19%)
Similarity:	240/693 - (34%)	Gaps:	195/693 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YRLIVFNLLEINLS----------NLMVFHCWSIKEAF--PLVEMLNQ----------------- 42
            |...:|..||.:|.          |::.|..::...||  ...:.|||
Human   240 YYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALS 304

  Fly    43 -----NGIFSQYIDVQNPDNLANVHKEYLDSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLH 102
                 :.:::....||.    .|..:|        :|| ..|.|..|::
Human   305 SALLFDAVYAVVTAVQE----LNRSQE--------IGV-KPLSCGSAQI---------------- 340

  Fly   103 WLLYDEAGNFTKLTQLFEGANLSLNADVTYVSREDEERFILHDVYNKGSHLGGKLNITVDQTLQC 167
            |.......|:.::.:| ||    |...:.:.|:.....:.|.           .|..|.:...|.
Human   341 WQHGTSLMNYLRMVEL-EG----LTGHIEFNSKGQRSNYALK-----------ILQFTRNGFRQI 389

  Fly   168 NRSHCQVKEYLS-ELHLRPRLQHRMDLSSVTFRLAALVSV------LPINSSEEELLEFLNSDRD 225
            .:.|  |.|.|| :.||     :..::|...|....:|:.      |.:..:.:|:   ..:||.
Human   390 GQWH--VAEGLSMDSHL-----YASNISDTLFNTTLVVTTILENPYLMLKGNHQEM---EGNDRY 444

  Fly   226 SH--MDSISRIGNRLIMHTQEILGF--KLHYIWCGTWSVQDAFG---GAIGMLTNESAELCTTPF 283
            ..  :|.:..:.        |||.|  |:..:..|.:.|.:|.|   |.:|.|....|:|...
Human   445 EGFCVDMLKELA--------EILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVA-- 499

  Fly   284 VPSWNRLHYLHPMTEQAQFRAVCMFRTPH-----------NAGIKAAV--FLEPFMPSVWFAFAG 335
                       .:|..|:...|..|..|.           :.|.|...  ||:||.|.||.....
Human   500 -----------GLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLL 553

  Fly   336 LLIFAGVLLWMIFHLERH-WMQ-------RCLDFIP--SLLSSCLISFGAACIQGSYLMPKSAGG 390
            ..:....:|:::..|..: |..       ||...:.  ||.:|.....|....|||.:.|::...
Human   554 AYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALST 618

  Fly   391 RL------AFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLAD-SSLDVGFDTVPFTKT 448
            |.      ||..::::|      ||:.:.:.|....:...|.::..||| ::::.|......:.|
Human   619 RCVSGVWWAFTLIIISS------YTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMT 677

  Fly   449 YLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPRE 513
            :..:|.....:.::....  .:.|:....|.|||:.|       |..|..:|:.......|..:.
Human   678 FFQNSRYQTYQRMWNYMY--SKQPSVFVKSTEEGIAR-------VLNSNYAFLLESTMNEYYRQR 733

  Fly   514 ISDLNEIILRPESAVYGM-VHLNSTYRQ----LLTQLQV---------RMLETGITSKQSRFFSK 564
            ..:|.:|....::..||: :.:.|.:|.    .:.|||.         :..|.|...|:....:|
Human   734 NCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAK 798

  Fly   565 TKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW 607
                        .:|||....:|:.|:....:|:.:.:||..|
Human   799 ------------GLGMENIGGIFVVLICGLIVAIFMAMLEFLW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	49/255 (19%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	36/206 (17%)
		ANF_receptor	43..382	CDD:279440	30/186 (16%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	80/408 (20%)
		Lig_chan	547..816	CDD:278489	57/295 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840