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Protein Alignment Ir75c and GRIK2

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	730	Identity:	143/730 - (19%)
Similarity:	251/730 - (34%)	Gaps:	226/730 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYLDSDLVRLGVFLDLGCDKAELVTNQSSRAR 95
            |:|.||::.:.:.                   ||:        .|..|...:.|..:..|:....
Human   209 KDAKPLLKEMKRG-------------------KEF--------HVIFDCSHEMAAGILKQALAMG 246

  Fly    96 LYNQNLHWLLYDEAGNFTKLTQL--------FEGANLS----LNADVTYVSREDE----ERF--- 141
            :..:..|::       ||.|...        :.|.|::    ||.:.|.||...|    ||.
Human   247 MMTEYYHYI-------FTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304

  Fly   142 -----------------ILHDVYNKGSHLGGKLNITVDQ-------TLQCNRSH-----CQVKEY 177
                             :::|..    |:   :::.|.|       :|||||..     .:....
Human   305 PKPDSGLLDGFMTTDAALMYDAV----HV---VSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSL 362

  Fly   178 LSELH---LRPR--------LQHRMDLSSVTFRLAALVSV-----------------LPINSS-- 212
            :.|.|   |..|        |:...||..::.:...|..:                 .|.|.:
Human   363 IKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDS 427

  Fly   213 ------------EEELLEFLNSDRDSHMDSISRIGN--------RLIMHTQEILGF--KLHYIWC 255
                        ||..:.|..||:..:       ||        .|:.....||||  ::..:..
Human   428 LSNRSLIVTTILEEPYVLFKKSDKPLY-------GNDRFEGYCIDLLRELSTILGFTYEIRLVED 485

  Fly   256 GTWSVQD----AFGGAIGMLTNESAELCTTPFVPSWNR---LHYLHP-MTEQAQFRAVCMFRTPH 312
            |.:..||    .:.|.:..|.:..|:|...|...::.|   :.:..| ||    .....::|.|:
Human   486 GKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMT----LGISILYRKPN 546

  Fly   313 NAGIKAAVFLEPFMPSVWFAFAGLLIFAGV--LLWMIFHLERH-WM--QRC---LDFIP---SLL 366
            ........||.|..|.:|...  ||.:.||  :|::|.....: |.  ..|   .|.:.   :||
Human   547 GTNPGVFSFLNPLSPDIWMYI--LLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLL 609

  Fly   367 SSCLISFGAACIQGSYLMPKSAGGRLA------FIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNI 425
            :|.....||...|||.||||:...|:.      |..::::|      ||:.:.:.|....:.|.|
Human   610 NSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISS------YTANLAAFLTVERMESPI 668

  Fly   426 RTIQQLA-DSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQ 489
            .:...|| .:.::.|......|.|:...|.......::  ...|.|..:.:..|.|||:.|
Human   669 DSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW--AFMSSRRQSVLVKSNEEGIQR---- 727

  Fly   490 PGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETG 553
               |.||:.:|:.......::.:...:|.:|....:|..||: ..:.|.||..:|...:::.|.|
Human   728 ---VLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEG 789

  Fly   554 ITSKQSRFFSKTKLHTFSNSF-------------VIQVGMEYAAPLFISLLVAYFLALLILILEI 605
                        |||.....:             ...:|::....:||.|.....|::.:.:.|.
Human   790 ------------KLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEF 842

  Fly   606 CW-----ARYAKKKF 615
            .:     |:..|:.|
Human   843 LYKSKKNAQLEKRSF 857

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.