DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and GRID1

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	772	Identity:	146/772 - (18%)
Similarity:	261/772 - (33%)	Gaps:	222/772 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSWPLYRL--IVFNLL-EINLSNLMVFHCWSIKEAFPLVEMLNQNGIFSQYIDVQNPD-NLANV 61
            :.|.|..||  ::..|: |:.....::|:. |..:...|...|:|.......:.:|..| |:::|
Human   141 LASRPPVRLNDVMLRLVTELRWQKFVMFYD-SEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHV 204

  Fly    62 HKEYLDS----------DLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLHW------------- 103
            ......:          |.:|..:.| |....|....|::....|.:::.||
Human   205 FTSLFTTMKTEELNRYRDTLRRAILL-LSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEIL 268

  Fly   104 -LLYDEAGNFTKLTQLFEGA-------------------------------NLSLNADVTYVSR- 135
             |::...|..|.:.|:|..|                               ||.|...|..::.
Human   269 DLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANA 333

  Fly   136 -----EDEE--------------------RFILHDVYNKGSHLGGK------------------- 156
                 ||.:                    |.:| |...|| |:.|.
Human   334 FHRKLEDRKWHSMASLNCIRKSTKPWNGGRSML-DTIKKG-HITGLTGVMEFREDSSNPYVQFEI 396

  Fly   157 LNITVDQTLQCNRSHCQVKEYLSELHLRPRLQHR---MDLSSVTFRLAALVSVL--PINSSEEEL 216
            |..|..:|.  .:...::..:.||..|...||.|   ..|..:|.:   :|:||  |.....|.:
Human   397 LGTTYSETF--GKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLK---VVTVLEEPFVMVAENI 456

  Fly   217 LEFLNSDRDSHMDSISRIGNRLIMHTQEILGFKL-----------HYIWCGTWSVQDAFGGAIGM 270
            |......:...:|.:..:.        :.||||.           |.:...:|:      |.||.
Human   457 LGQPKRYKGFSIDVLDALA--------KALGFKYEIYQAPDGRYGHQLHNTSWN------GMIGE 507

  Fly   271 LTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVF--LEPFMPSVWFAF 333
            |.::.|:|..:....:..|...:........:....:.:.|..   |.::|  ..||..:||...
Human   508 LISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEE---KISIFSLFAPFDFAVWACI 569

  Fly   334 AGLLIFAGVLLWMIFHLERHWMQRCLDFIPS----LLSSCLISFGAACIQGSYLMPKSAGGRLAF 394
            |..:...|||::::..::....|......||    |.|:..|.:||...||......|...|:..
Human   570 AAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVM 634

  Fly   395 IAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIR 459
            .:..|.:.::.:.||:.:.:.|..|.:.:.|||.|.|: ..:::.:.||..:..|
Human   635 GSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLS-KQVEMSYGTVRDSAVY---------- 688

  Fly   460 SLYKQKVESKRDPNS----VW-------------LSPEEGVIRVRDQPGFVYTSEASFMYHFVEK 507
            ..::.|..:..:.:|    :|             .||.||:.:.:       ....:|::.....
Human   689 EYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAK-------KGNYAFLWDVAVV 746

  Fly   508 HYLPREISDLNEIIL--RPESAVYGM-VHLNSTYRQLLTQLQVRMLETG---------------- 553
            .|......|.:..::  ...|..||: :...|.||.|.:|..:.:.:||
Human   747 EYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRC 811

  Fly   554 -ITSKQSRFF--SKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW 607
             :||..|...  ...|||:|:..|.|             |.:...||.|:..||:.|
Human   812 DLTSHASAQADGKSLKLHSFAGVFCI-------------LAIGLLLACLVAALELWW 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	49/248 (20%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		53/300 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	49/287 (17%)
		ANF_receptor	41..400	CDD:279440	44/262 (17%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	77/407 (19%)
		Lig_chan	564..841	CDD:278489	61/307 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155852
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740