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Protein Alignment Ir75c and GRIA2

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	710	Identity:	138/710 - (19%)
Similarity:	254/710 - (35%)	Gaps:	193/710 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NPDNLANVHKE------YLDSDLVR-LGVFLDLGCDKAELVTNQSSRARLYNQNLHWLLYD---E 108
            |..|:.|..|:      :.|.:|.: ..|.||...||...:.:|......:.:..|:::.:   .
Human   179 NVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFT 243

  Fly   109 AGNFTKLTQLFEGANLS----LNADVTYVSREDEERFILHDVYNKGSHLGGKLNITVDQTLQCNR 169
            .|:..|:.  |.|||:|    ::.|.:.||:..|....|.:....|:|     ..|:..|.....
Human   244 DGDLLKIQ--FGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAH-----TTTIKYTSALTY 301

  Fly   170 SHCQVKEYLSELHLRPRLQHRMDLS------------------------------------SVTF 198
            ...||   ::|.....|.| |:::|                                    ::.|
Human   302 DAVQV---MTEAFRNLRKQ-RIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKF 362

  Fly   199 -----RLAALVSVLPINS---------SEEELLEFLNSDRDSHMDSISRIGNRLIMHT------- 242
                 |:...::::.:.:         ||.:.:....::..|..|: |.:.|:.::.|
Human   363 DQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDT-SGLENKTVVVTTILESPY 426

  Fly   243 ------QEIL---------------------GF--KLHYIWCGTWSVQDA----FGGAIGMLTNE 274
                  .|:|                     ||  ||..:..|.:..:||    :.|.:|.|...
Human   427 VMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYG 491

  Fly   275 SAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIF 339
            .|::...|...:..|...:.............|.:.|..:......||:|....:|.......|.
Human   492 KADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIG 556

  Fly   340 AGVLLWMI-------FHLERHWMQRCLDFIPS-----LLSSCLISFGAACIQGSYLMPKSAGGRL 392
            ..|:|:::       :|.|.....|......|     :.:|...|.||...||..:.|:|..||:
Human   557 VSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRI 621

  Fly   393 A-----FIAVMLTSFLMYNYYTSIVVSTLLGSPVRS--NIRTIQQLADSSLDVGFDTVPFTK--- 447
            .     |..:::.|....|....:.|..:: ||:.|  ::....::|..:||.| .|..|.:
Human   622 VGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLSKQTEIAYGTLDSG-STKEFFRRSK 684

  Fly   448 --------TYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPG-FVYTSEASFMYH 503
                    ||:.|:                 :|:....:..|||.|||...| :.|..| |.|..
Human   685 IAVFDKMWTYMRSA-----------------EPSVFVRTTAEGVARVRKSKGKYAYLLE-STMNE 731

  Fly   504 FVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSK-QSRFF---- 562
            ::|:    |:..|..::....:|..||: ....|:.|..:....:::.|.|:..| :::::
Human   732 YIEQ----RKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKG 792

  Fly   563 --------SKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICWARYAKKK 614
                    ||.|....|.|.|        |.:|..|:....||:|:.::|.|:...|:.|
Human   793 ECGAKDSGSKEKTSALSLSNV--------AGVFYILVGGLGLAMLVALIEFCYKSRAEAK 844

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.