DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75c and GRIA1

DIOPT Version :9

Sequence 1:NP_649013.3 Gene:Ir75c / 39983 FlyBaseID:FBgn0261401 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_001244950.1 Gene:GRIA1 / 2890 HGNCID:4571 Length:916 Species:Homo sapiens


Alignment Length:706 Identity:149/706 - (21%)
Similarity:263/706 - (37%) Gaps:134/706 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 YRLIVFNLLEINLSNLMVFHCWS--IKEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYLDSD 69
            ||:: |..||.....|:|..|.|  :......:..|.:|||...||       |||:  .::|.|
Human   195 YRML-FQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYI-------LANL--GFMDID 249

  Fly    70 LVRLGVFLDLGCDKA--ELVT-NQSSRARLYNQ----------NLHW--------LLYDEAGNFT 113
            |.:   |.:.|.:..  :||. ..:..|::..|          .:.|        |.||......
Human   250 LNK---FKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMA 311

  Fly   114 KLTQLFEGANLSL-----------NADVTYVSREDEERFILHDVYNKG-------SHLGGKLNIT 160
            :..|......:.:           |..|.:....|.:| .|..|..:|       :..|.:.|.|
Human   312 EAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQR-ALQQVRFEGLTGNVQFNEKGRRTNYT 375

  Fly   161 VDQTLQCNRSHCQVKEYLSE----LHLRPRLQHRMDLSSVTFRLAALVSVL--PINSSEEELLEF 219
            : ..::......:...|.:|    :......|...|.|||..|...:.::|  |....::...:|
Human   376 L-HVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQF 439

  Fly   220 LNSDRDSHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWSVQD----AFGGAIGMLTNESAELCT 280
            ..:||  :......:...:..|..  ..::|..:..|.:..:|    |:.|.:|.|....|::..
Human   440 EGNDR--YEGYCVELAAEIAKHVG--YSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAV 500

  Fly   281 TPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLW 345
            .|...:..|...:.............|.:.|..:......||:|....:|.......|...|:|:
Human   501 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 565

  Fly   346 MI-------FHLERHWMQRCLDFIPS-------LLSSCLISFGAACIQGSYLMPKSAGGRLA--- 393
            ::       :|.|.  .:...|...|       :.:|...|.||...||..:.|:|..||:.   
Human   566 LVSRFSPYEWHSEE--FEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 628

  Fly   394 --FIAVMLTSFLMYNYYTSIVVSTLLGSPVRS--NIRTIQQLADSSLDVGFDTVPFTKTYLVSSP 454
              |..:::.|....|....:.|..:: ||:.|  ::....::|..:|:.|     .||.:.   .
Human   629 WWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLEAG-----STKEFF---R 684

  Fly   455 RPDIRSLYKQKVESKRDPNSVWL-SPEEGVIRVRDQPG-FVYTSEASFMYHFVEKHYLPREISDL 517
            |..|....|.....|....||:: :.|||:||||...| :.|..| |.|..::|:    |:..|.
Human   685 RSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLE-STMNEYIEQ----RKPCDT 744

  Fly   518 NEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSK-QSRFF------------SKTKLH 568
            .::....:|..||: ....|..|..:....:::.|.|:..| :::::            ||.|..
Human   745 MKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTS 809

  Fly   569 TFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW-ARYAKKKFS--TIIPQ 621
            ..|.|.|        |.:|..|:....||:|:.::|.|: :|...|:..  .:|||
Human   810 ALSLSNV--------AGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQ 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir75cNP_649013.3 Lig_chan 328..553 CDD:306551 57/248 (23%)
GRIA1NP_001244950.1 PBP1_iGluR_AMPA_GluR1 36..399 CDD:107385 44/218 (20%)
ANF_receptor 47..382 CDD:279440 42/201 (21%)
PBP2_iGluR_AMPA_GluR1 416..797 CDD:270447 81/400 (20%)
Lig_chan 548..827 CDD:278489 68/302 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155900
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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