DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and Grin2d

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	87/472 - (18%)
Similarity:	152/472 - (32%)	Gaps:	170/472 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 MDSISRIGNR------LIMHTQEILGFKLHYIWCGTWSVQDAF----GGAIGMLT--NESAELC- 279
            :|.:.|:.:.      |.:.|....|.|:..:|.|  .:.:.|    ..|||.||  .|.:|:.
  Rat   486 IDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNG--MIGEVFYQRADMAIGSLTINEERSEIVD 548

  Fly   280 -TTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFL-----------EPFMPSVW-F 331
             :.|||.:                 .:.:.....|..:..:.||           ||:.|:|| .
  Rat   549 FSVPFVET-----------------GISVMVARSNGTVSPSAFLAFAWLTPPMSPEPYSPAVWVM 596

  Fly   332 AFAGLLIFAGVLLWMIFHL-----------------------ERHWMQRCLDF---IP------- 363
            .|...|....|.:::..:|                       :..|:...|.|   :|
  Rat   597 MFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGT 661

  Fly   364 -SLLSSCLISFGAACIQGSYLMPKSAGGRLAFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRT 427
             |.:...:.:|.|.....||             ...|.:|::...|    |.|:.|    .:.|.
  Rat   662 TSKIMVLVWAFFAVIFLASY-------------TANLAAFMIQEEY----VDTVSG----LSDRK 705

  Fly   428 IQQLADSSLDVGFDTVPFTKT-------------YLVSSPRPDIRSLYKQKVESKRDPNSVWLSP 479
            .|:..:....:.|.|||...|             |:|...:|.:.....|....|.|
  Rat   706 FQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLD-------- 762

  Fly   480 EEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRP----ESAVYGM-VHLNSTYR 539
                               :|:|.....:|:.|:......:.:..    .:..||: :|..|.::
  Rat   763 -------------------AFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWK 808

  Fly   540 --------QLLTQLQVRMLE----TGITSKQSRFFSKTKLHTFSNSFVIQVGMEYAAPLFISLLV 592
                    |.|...::.|||    :||....       |:...|:    ::.::..|.:|..|||
  Rat   809 RPIDLALLQFLGDDEIEMLERLWLSGICHND-------KIEVMSS----KLDIDNMAGVFYMLLV 862

  Fly   593 AYFLALLILILE--ICW 607
            |..|:||:...|  :.|
  Rat   863 AMGLSLLVFAWEHLVYW 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	47/289 (16%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	74/418 (18%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830