DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75c and Grin2a

DIOPT Version :9

Sequence 1:NP_649013.3 Gene:Ir75c / 39983 FlyBaseID:FBgn0261401 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:578 Identity:104/578 - (17%)
Similarity:189/578 - (32%) Gaps:171/578 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 TSWPLYRLIVFNLLEINLSNLMVFHCWSIKEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYL 66
            |.:|.||..: :.::..:.|..|  .|         :|.|...:.:.:.|.:....|..:|... 
  Rat   175 TIFPGYRDFI-SFIKTTVDNSFV--GW---------DMQNVITLDTSFEDAKTQVQLKKIHSSV- 226

  Fly    67 DSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLHWLLYD-EAGNFTKLTQLFEGANLSLNAD- 129
                    :.|....|:|.|:.:::....|...:..|::.. .:||...:.:.|....:|::.| 
  Rat   227 --------ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDD 283

  Fly   130 ---------------VTYVSREDEERFI-------------------LHDVY------------- 147
                           :|..:....|:|.                   ||.::             
  Rat   284 WDYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASCYGQAEKPETPLHTLHQFMVNVTWDGKDL 348

  Fly   148 ---NKGSHLGGKLNITV--------------DQTLQCNRSHCQVKEYLSELHLRPRLQHRMDLSS 195
               .:|..:..:|.:.|              :|||...  |.....|.|.....|...|   ||.
  Rat   349 SFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTLSLR--HAVWPRYKSFSDCEPDDNH---LSI 408

  Fly   196 VTFRLAALVSV--------------------LPINSSEEELLEFLNSDRDSHMDSISRIGNRLIM 240
            ||...|..|.|                    :.||:|..|.:......:...:|.:.:: :|.:.
  Rat   409 VTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKL-SRTVK 472

  Fly   241 HTQEIL-------GFKLHYIWCGTWS--VQDAFGGAIGMLT--NESAELC--TTPFVPSWNRLHY 292
            .|.::.       |.|::.:|.|...  |......|:|.||  .|.:|:.  :.|||.:      
  Rat   473 FTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVET------ 531

  Fly   293 LHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVW-FAFAGLLIFAGVLLWMIFHL-----E 351
                       .:.:..:..|..:..:.|||||..||| ..|..|||.:.:.:::..:.     .
  Rat   532 -----------GISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYN 585

  Fly   352 RHWMQRCLDFIPSL-------LSSCLISFGAACIQGSYLMPKSAGGRL-----AFIAVMLTSFLM 404
            |:..:......||.       |...|:...:..:|.    ||....::     ||.||:..:...
  Rat   586 RNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQN----PKGTTSKIMVSVWAFFAVIFLASYT 646

  Fly   405 YNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLY 462
            .|....::....:......:.:..|:..|.|....|.|||      ..|...:||:.|
  Rat   647 ANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVP------NGSTERNIRNNY 698

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir75cNP_649013.3 Lig_chan 328..553 CDD:306551 31/153 (20%)
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 35/239 (15%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 66/327 (20%)
HisJ <458..>541 CDD:223904 17/100 (17%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 31/153 (20%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 2/20 (10%)