DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and Grin3a

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	742	Identity:	161/742 - (21%)
Similarity:	258/742 - (34%)	Gaps:	244/742 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VFNLLEINLSN-------LMVFHC--WSIKEAFPLVEMLNQNGIFSQYIDVQNPD---------N 57
            :.:.|::.|.|       :::|.|  .||::.|   ||..|.|:       ..||         |
Mouse   307 LLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIF---EMSTQFGL-------SPPDLHWVLGDSQN 361

  Fly    58 LANVHKEYLDSDLVRLG-----VFLDLGCDKAELVTNQSSRARLYNQNLHWLLYDEAGNFTKLTQ 117
            :..:..|.|...|:..|     ||.....|..|||....:.|.:....|..|.........|.|.
Mouse   362 VEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTN 426

  Fly   118 LFEGANLS----------LNADV-----TYVSREDEERFIL----HDVYNK------GSHLGGKL 157
            |..|..||          |:..:     |.||  .|..|.:    :|...|      ||..||:
Mouse   427 LTSGQYLSRFLANTTFRGLSGSIKVKGSTIVS--SENNFFIWNLQYDPMGKPMWTRLGSWQGGR- 488

  Fly   158 NITVD-----QTLQCNRSHCQVKEYLSELHLR---------------------PRLQHRMD---- 192
             |.:|     :..|.:::|.   .:.::||||                     |..|..:|
Mouse   489 -IVMDSGIWPEQAQRHKTHF---HHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTN 549

  Fly   193 ----LSSVTFRLAALVSVLPINSSE----------EELLEFLNSDRDSHMDSISRIGNRLIMHTQ 243
                |.|:...|.:....:||...:          |:|.|.:|.|.|.:
Mouse   550 DSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLY---------------- 598

  Fly   244 EILGFKLHYIW-CGTWSVQDAFGGAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCM 307
             |:|...:..| .|.|:      |.:|.|.:.:|.:..|.|  |.|        |.::|   |..
Mouse   599 -IVGDGKYGAWKNGHWT------GLVGDLLSGTANMAVTSF--SIN--------TARSQ---VID 643

  Fly   308 FRTPH---NAGI-----KAAVFLEPFM-PSVWFAFAGLLIFAGVLLWMIFHLERHW--------- 354
            |.:|.   :.||     ..|..:..|| |..|..:.|  ||..:.:..||.....|
Mouse   644 FTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLG--IFVALHITAIFLTLYEWKSPFGMTPK 706

  Fly   355 ---MQRCLDFIPSLLSSCLISFG-AACIQGSYLMPKSAGGRLAFIAVMLTSFLMY--NYYTSIVV 413
               ..:...|..:|.....:.|| .|.|:    .||...||  |:..:...|.|:  :.||:.:.
Mouse   707 GRNRNKVFSFSSALNVCYALLFGRTAAIK----PPKCWTGR--FLMNLWAIFCMFCLSTYTANLA 765

  Fly   414 STLLGSPVRSNIRTIQ--QLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVW 476
            :.::|..:...:..|.  :|...|....|.||      ..||....:|..:.:..|..|..| |.
Mouse   766 AVMVGEKIYEELSGIHDPKLHHPSQGFRFGTV------RESSAEDYVRQSFPEMHEYMRRYN-VP 823

  Fly   477 LSPEEGVIRVRDQP----GFVYTSEASFMYHFVEKHYLPREIS---DLNEIILRPESAV--YGM- 531
            .:| :||..:::.|    .|:           ::|..|..|:|   |...:.:....|:  ||:
Mouse   824 ATP-DGVQYLKNDPEKLDAFI-----------MDKALLDYEVSIDADCKLLTVGKPFAIEGYGIG 876

  Fly   532 VHLNSTYRQLLTQLQVRMLETGITSKQSRFFSKTKLHTF---------------SNSFVI----Q 577
            :..||.                :||..|...|:.|.|.|               ..||.:    |
Mouse   877 LPPNSP----------------LTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQ 925

  Fly   578 VGMEYAAPLFISLLVAYFLALLILILE 604
            :|:::.:.||:.|.:.:.|::|..|.|
Mouse   926 MGIKHFSGLFVLLCIGFGLSILTTIGE 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	51/251 (20%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	48/203 (24%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	100/474 (21%)
		Lig_chan	676..942	CDD:278489	64/308 (21%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		1/2 (50%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830