DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and Grin3b

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	95/469 - (20%)
Similarity:	153/469 - (32%)	Gaps:	144/469 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 RLAALVSVLPINSSEEELLEFLNSDRDSH---MDSISRIGNRLIMHTQEILGFKLHYIWCGTW-S 259
            ||.||.:.| :|.|....|.     |..:   :|.:.|:...|      ...|:|:.:..|.: :
  Rat   455 RLDALFAAL-VNGSVPRTLR-----RCCYGYCIDLLERLAEDL------AFDFELYIVGDGKYGA 507

  Fly   260 VQDA-FGGAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLE 323
            ::|. :.|.:|.|....|.:..|.|..:..|...:...:.........|.||...|. ....|:.
  Rat   508 LRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTAS-PIGAFMW 571

  Fly   324 PFMPSVWFAFAGLLIFAGVLLWMIFHLERHW----------MQRCLDF-IPSLLSSC-LISFGAA 376
            |...|:|..     :||.:.|..:|.....|          ..|...| ..|.|:.| .|.||..
  Rat   572 PLHWSMWVG-----VFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRT 631

  Fly   377 CIQGSYLMPKSAGGRLAFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLA---DSSLDV 438
            .   |...||...||.......:...|:.:.||:.:.:.::|.      :|.::|:   |..|
  Rat   632 V---SSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGD------KTFEELSGIHDPKL-- 685

  Fly   439 GFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASF--M 501
                         ..|....|.            .:||.|..|..|:            |||  |
  Rat   686 -------------HHPSQGFRF------------GTVWESSAEAYIK------------ASFPEM 713

  Fly   502 YHFVEKHYLPRE-------ISD---LNEIILRPESAVYGMVHLNSTYRQLLTQLQVRMLETG--- 553
            :..:.:|..|..       .||   ||..|:......|          ::......::|..|
  Rat   714 HAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDY----------EVSIDADCKLLTVGKPF 768

  Fly   554 --------------ITSKQSRFFSKTK-------LH------------TFSNSFVIQVGMEYAAP 585
                          :||..|.|.|:.|       ||            .|:.:..:|:|:.:.:.
  Rat   769 AIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHFSG 833

  Fly   586 LFISLLVAYFLALL 599
            ||:.|.:....|||
  Rat   834 LFVLLCLGLGSALL 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	48/251 (19%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	86/428 (20%)
		Lig_chan	576..842	CDD:278489	63/328 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930