DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and gria3a

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	743	Identity:	128/743 - (17%)
Similarity:	254/743 - (34%)	Gaps:	215/743 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LSNLMVFHCW-------SIKEAFPLVEMLNQNGIFSQY-IDVQNPDNLAN--------------V 61
            |.:|:..:.|       .....|.:::.:.::.:.:.: :..::..|:.:              .
Zfish   142 LLSLLAHYKWEKFVYLYDTDRGFSILQAIMESAVMNNWQVTARSVGNIVDPLEYRRIIEEMDRRQ 206

  Fly    62 HKEYL-DSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLHWLLYDEAGNFTKLTQLFE-GANL 124
            .|.:| |.::.|:...|:     ..::..::||      ..|::|.:.......|.::|. |||:
Zfish   207 EKRFLIDCEVERINSILE-----QVVIAGKNSR------GYHYILANLGFTNMSLDKVFSGGANI 260

  Fly   125 S----LNADVTYV-------SREDEERF-------------ILH------------------DVY 147
            :    :|.|...|       .|.||..|             :.|                  |:.
Zfish   261 TGFQIINPDSPIVQQFLQRWERLDEREFPESRSSPLKYTSALTHDAILVIAEAFRYLRRQRVDIS 325

  Fly   148 NKGSHLGGKL---------NITVDQTLQC----------------NRSHCQVKEYLSELHLRP-- 185
            .:|| .|..|         .|.:::.|:.                .||:..|..|    .::|
Zfish   326 RRGS-AGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRSNYTVDVY----EMKPGG 385

  Fly   186 -----------------RLQHRMDLSSVTFRLAALVSVL--PINSSEEELLEFLNSDR------D 225
                             ..|...:.|||..|...:.:::  |....:...::...:||      |
Zfish   386 ARKIGYWNEFEKFVYIVEQQVTNESSSVENRTIVVTTIMEAPYVMYKRNYMQLEGNDRYEGYCVD 450

  Fly   226 SHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWSVQD----AFGGAIGMLTNESAELCTTPFVPS 286
            ...:....:|          :.:||..:..|.:..:|    .:.|.:|.|....|::...|...:
Zfish   451 LASEIAKHVG----------IKYKLSIVADGKYGARDPETKTWNGMVGELVYGRADIAVAPLTIT 505

  Fly   287 WNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLWMI---- 347
            ..|...:.............|.:.|..:......||:|....:|.......|...|:|:::
Zfish   506 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 570

  Fly   348 ---FHLERHWMQRCLDFIP------SLLSSCLISFGAACIQGSYLMPKSAGGRLA-----FIAVM 398
               :||:.:...:.....|      .:.:|...|.||...||..:.|:|..||:.     |..::
Zfish   571 PYEWHLDDNEETKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 635

  Fly   399 LTSFLMYNYYTSIVVSTLLGSPVRS--NIRTIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIRSL 461
            :.|....|....:.|..:: ||:.|  ::....::|..:||.|.....|.::.:         ::
Zfish   636 IISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI---------AV 690

  Fly   462 YKQ--KVESKRDPNSVWLSPEEGVIRVRDQPG-FVYTSEASFMYHFVEKHYLPREISDLNEIILR 523
            |::  ......:|:....:..:||.|||...| |.:..| |.|..::|:    |:..|..::...
Zfish   691 YEKMWSYMKSAEPSVFVKTTPDGVARVRKSKGKFAFLLE-STMNEYIEQ----RKPCDTMKVGGN 750

  Fly   524 PESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSK-QSRFF------------SKTKL------- 567
            .:|..||: ....|..|..:....:::.|.||..| :::::            ||..|
Zfish   751 LDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGTKDSGSKVSLLTHLTVL 815

  Fly   568 -------HTFSNSFVIQVGMEYAAPLFI 588
                   |...|.|.: .|..:..||||
Zfish   816 PTNISIYHKHHNEFPV-AGFTFFWPLFI 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	50/248 (20%)
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	39/272 (14%)
		ANF_receptor	39..382	CDD:279440	38/255 (15%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	74/406 (18%)
		Lig_chan	547..810	CDD:278489	56/277 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840