DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and gria2b

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	770	Identity:	151/770 - (19%)
Similarity:	268/770 - (34%)	Gaps:	217/770 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 HCWSIKEAFPLVEMLNQNGIFSQYIDVQNP----------DNLANVHKEYLDSD--LVRLGVFLD 78
            |...|..:|||..  ||..|.....|::.|          |..|.::    |||  |..|.|.||
Zfish   107 HVSFITPSFPLDG--NQQFIIQMRPDIKGPLLSLIEYYKWDKFAYLY----DSDRGLTTLQVVLD 165

  Fly    79 LGCDKAELVT------------------------NQSSRARLYN--------------------Q 99
            ...:|...||                        |:..|..:.:                    :
Zfish   166 TAAEKKWQVTAINVGNMKDERKDEAYRSLFQDLENKKERRVILDCEQDKVKDIMEQVITIGRHVK 230

  Fly   100 NLHWLLYDEA---GNFTKLTQLFEGANLS----LNADVTYVSREDEERFILHDVYNKGSHLGGKL 157
            ..|:::.:..   |:.:|:.  :.|||:|    ::.|...||:.|:....|.:....|:  ..|:
Zfish   231 GYHYIIANLGFVDGDLSKIQ--YGGANVSGFQIVDFDDPLVSKFDQRWEALEEKEYPGA--DSKI 291

  Fly   158 NIT----------------------VDQTLQCNRSHC------------QVKEYLSELHLRPRLQ 188
            ..|                      :|.:.:.|...|            :::..|.::.: ..|.
Zfish   292 RYTSALTYDAVQVMTEAFRYLHKQRIDISRRANNGDCLANPAVPWAQGVEIERALKQVRV-DGLT 355

  Fly   189 HRMDLSSVTFRLAALVSVLPINSS-----------------------------EEE------LLE 218
            ..:.......|:...|:|:.:.|:                             |.:      :||
Zfish   356 GNIQFDQYGKRVNYTVNVMELKSNGAVKIGYWNEVDKMVVTKSDLFPNDTMGLENKTVIVTTILE 420

  Fly   219 ----FLNSDRDSHMDSISRIGNRLIMHTQEI---LGFK--LHYIWCGTWSVQDA----FGGAIGM 270
                .|..:.|..||: .|.....:....||   .|||  |..:..|.:..:||    :.|.:|.
Zfish   421 APYVMLKKNADLFMDN-ERYEGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIWNGMVGE 484

  Fly   271 LTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAG 335
            |....|::...|...:..|...:.............|.:.|..:......||:|....:|.....
Zfish   485 LVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVF 549

  Fly   336 LLIFAGVLLWMI-------FHLERH------WMQRCLDFIPSLLSSCLISFGAACIQGSYLMPKS 387
            ..|...|:|:::       :|.|.:      ..:...:|  .:.:|...|.||...||..:.|:|
Zfish   550 AYIGVSVVLFLVSRFSPYEWHTEEYEDGQIQTNESTNEF--GIFNSLWFSLGAFMRQGCDISPRS 612

  Fly   388 AGGRLA-----FIAVMLTSFLMYNYYTSIVVSTLLGSPVRS--NIRTIQQLADSSLDVGFDTVPF 445
            ..||:.     |..:::.|....|....:.|..:: ||:.|  ::....::|..:||.|     .
Zfish   613 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDSG-----S 671

  Fly   446 TKTYLVSSPRPDIRSLYKQKVESKRDPNSVWL-SPEEGVIRVRDQPG-FVYTSEASFMYHFVEKH 508
            ||.:.   .|..|....|.....|....||:: :..|||:|||...| :.|..| |.|..::|:
Zfish   672 TKEFF---RRSKIALFDKMWTYMKGAEPSVFVKTTAEGVMRVRKSKGKYAYLLE-STMNEYIEQ- 731

  Fly   509 YLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSK-QSRFF--------- 562
               |:..|..::....:|..||: ....|:.|..:....:::.|.|:..| :::::
Zfish   732 ---RKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG 793

  Fly   563 ---SKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICWARYAKKK 614
               ||.|....|.|.|        |.:|..|:....||:|:.::|.|:...|:.|
Zfish   794 GGDSKEKTSALSLSNV--------AGVFYILVGGLGLAMLVALVEFCYKSRAEAK 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	56/247 (23%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	49/298 (16%)
		ANF_receptor	55..377	CDD:279440	48/280 (17%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	85/396 (21%)
		Lig_chan	542..820	CDD:278489	67/301 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591248
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840