DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and gria2a

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	706	Identity:	140/706 - (19%)
Similarity:	250/706 - (35%)	Gaps:	191/706 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NLANVHKEYLD-------SDLVRLG---VFLDLGCDKAELVTNQSSRARLYNQNLHWLLYDEA-- 109
            |:.|:..|:.|       .||....   |.||...||.:.:..|......:.:..|:::.:..
Zfish   174 NVGNLKDEWKDEAYRSLFQDLENKNERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIANFGFV 238

  Fly   110 -GNFTKLTQLFEGANLS----LNADVTYVSREDE------------------------------- 138
             |:.:|:.  :.|||:|    ::.|...|::.|:
Zfish   239 DGDLSKIQ--YGGANVSGFQIVDFDDPLVAKFDQRWEALEEKEYPGADSRIRYTSALTYDAVQVM 301

  Fly   139 -ERF-ILH----DVYNKGSH-------------------------------------LGGKLNIT 160
             |.| .||    |:..:|::                                     .|.::|.|
Zfish   302 TEAFRFLHKQRIDISRRGNNGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGRRVNYT 366

  Fly   161 VDQTLQCNRSHCQV-------KEYLSELHLRPRLQHRMDLSS--VTFRLAALVSVLPINSSEEEL 216
            |:.....|....::       |..:::..|.|.....|:..:  ||..|.|...:|..|:.
Zfish   367 VNVMELKNSGPVKIGYWNEMDKMAVTKSDLFPNDTMGMENKTVIVTTILEAPYVMLKKNAE---- 427

  Fly   217 LEFLNSDRDSHMDSISRIGNRLIMHTQEILGFK--LHYIWCGTWSVQDA----FGGAIGMLTNES 275
               |.:|.:.:......:...:..|    .|||  |..:..|.:..:||    :.|.:|.|....
Zfish   428 ---LFTDNERYEGYCVDLAAEIAKH----CGFKYQLRIVADGKYGARDAETKIWNGMVGELVYGK 485

  Fly   276 AELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFA 340
            |::...|...:..|...:.............|.:.|..:......||:|....:|.......|..
Zfish   486 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGV 550

  Fly   341 GVLLWMI-------FHLERHWMQRCLDFI-----PS-------LLSSCLISFGAACIQGSYLMPK 386
            .|:|:::       :|.|        :|.     ||       :.:|...|.||...||..:.|:
Zfish   551 SVVLFLVSRFSPYEWHTE--------EFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQGCDISPR 607

  Fly   387 SAGGRLA-----FIAVMLTSFLMYNYYTSIVVSTLLGSPVRS--NIRTIQQLADSSLDVGFDTVP 444
            |..||:.     |..:::.|....|....:.|..:: ||:.|  ::....::|..:||.|
Zfish   608 SLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDAG----- 666

  Fly   445 FTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWL-SPEEGVIRVRDQPG-FVYTSEASFMYHFVEK 507
            .||.:.   .|..|....|.....|....||:: :..|||:|||...| :.|..| |.|..::|:
Zfish   667 STKEFF---RRSKIALFDKMWQYMKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLE-STMNEYIEQ 727

  Fly   508 HYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSK-QSRFF-------- 562
                |:..|..::....:|..||: ....|..|..:....:::.|.|:..| :::::
Zfish   728 ----RKPCDTMKVGGNLDSKGYGIATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 788

  Fly   563 ----SKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICWARYAKKK 614
                ||.|....|.|.|        |.:|..|:....||:|:.::|.|:...|:.|
Zfish   789 GGGESKEKTSALSLSNV--------AGVFYILVGGLGLAMLVALVEFCYKSRAEAK 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	58/253 (23%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	34/218 (16%)
		ANF_receptor	51..373	CDD:279440	32/200 (16%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	87/409 (21%)
		Lig_chan	538..816	CDD:278489	69/307 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840