Protein Alignment Ir75c and Grin2d

DIOPT Version :10

• Sequence 1: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_036008580.1
• Gene: Grin2d / 14814
• MGIID: 95823
• Length: 1345
• Species: Mus musculus
• Alignment Length: 639
• Identity: 121/639 - (18%)
• Similarity: 209/639 - (32%)
• Gaps: 194/639 - (30%)

  Fly    74 GVFLDLGCD-KAELVTNQSSRARLYNQNLHW----LLYDEAGNFTKLTQLFEGANLSLNADVTYV 133
            |...:||.| :|:..|::......|..|:.|    ..::|.|.....:.:.    :||..|.|:.
Mouse   341 GFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVV----ISLTRDRTWE 401

  Fly   134 SREDEERFILHDVYNKGSHLGGKLNITVDQTLQCNRSHCQVKEY--------LSELHLRPRLQHR 190
            .....|:..|...|...|..|..|. .||.|.....:..:.:.:        :|...:|..:..|
Mouse   402 VVGSWEQQTLRLKYPLWSRYGRFLQ-PVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCR 465

  Fly   191 MDLSSVTFRLAALVSVLPINSSEEELLEFLNSDRDSHMDSISRIGNR------LIMHTQEILGFK 249
            ..|:. |..|.|..|..|.....|:     ...:...:|.:.|:.:.      |.:.|....|.|
Mouse   466 SQLNR-THSLVAPRSPPPDAPRPEK-----RCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKK 524

  Fly   250 LHYIWCGTWSVQDAF----GGAIGMLT--NESAELC--TTPFVPSWNRLHYLHPMTEQAQFRAVC 306
            :..:|.|  .:.:.|    ..|||.||  .|.:|:.  :.|||.:                 .:.
Mouse   525 IDGVWNG--MIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVET-----------------GIS 570

  Fly   307 MFRTPHNAGIKAAVFL-----------EPFMPSVW-FAFAGLLIFAGVLLWMIFHL--------- 350
            :.....|..:..:.||           ||:.|:|| ..|...|....|.:::..:|
Mouse   571 VMVARSNGTVSPSAFLAFAWLMPPMSPEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSL 635

  Fly   351 --------------ERHWMQRCLDF---IP--------SLLSSCLISFGAACIQGSYLMPKSAGG 390
                          :..|:...|.|   :|        |.:...:.:|.|.....||
Mouse   636 ATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASY-------- 692

  Fly   391 RLAFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTVPFTKT------- 448
                 ...|.:|::...|    |.|:.|    .:.|..|:..:....:.|.|||...|
Mouse   693 -----TANLAAFMIQEEY----VDTVSG----LSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSN 744

  Fly   449 ------YLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEK 507
                  |:|...:|.:.....|....|.|                           :|:|.....
Mouse   745 YPDMHSYMVRYNQPRVEEALTQLKAGKLD---------------------------AFIYDAAVL 782

  Fly   508 HYLPREISDLNEIILRP----ESAVYGM-VHLNSTYR--------QLLTQLQVRMLE----TGIT 555
            :|:.|:......:.:..    .:..||: :|..|.::        |.|...::.|||    :||.
Mouse   783 NYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGIC 847

  Fly   556 SKQSRFFSKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILE--ICW 607
            ...       |:...|:    ::.::..|.:|..||||..|:||:...|  :.|
Mouse   848 HND-------KIEVMSS----KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYW 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	36/227 (16%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:471960	17/77 (22%)
		PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	84/489 (17%)