DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and Grin2c

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_017169765.1	Gene:	Grin2c / 14813	MGIID:	95822	Length:	1307	Species:	Mus musculus

Alignment Length:	388	Identity:	76/388 - (19%)
Similarity:	138/388 - (35%)	Gaps:	93/388 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 AIGMLT--NESAELC--TTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMP 327
            |||.||  .|.:|:.  :.|||.:                 .:.:.....|..:..:.||||:.|
Mouse   568 AIGSLTINEERSEIIDFSVPFVET-----------------GISVMVARSNGTVSPSAFLEPYSP 615

  Fly   328 SVW-FAFAGLLIFAGVLLWMIFHLERHWMQRCLDFIPSLLSSCLISFGAACIQG------SYLMP 385
            :|| ..|...|....:.::|..:           |.|       :|:.....:|      |:.:.
Mouse   616 AVWVMMFVMCLTVVAITVFMFEY-----------FSP-------VSYNQNLTKGKKSGGPSFTIG 662

  Fly   386 KSA-----------------GGRLAFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLAD 433
            ||.                 .|..:.|.|::.:|....:..|...:..........|.|:..|:|
Mouse   663 KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSD 727

  Fly   434 SSLD--------VGFDTVPFTKTYLVSSPRPDIRSLYKQKVE-SKRDPNSVWLSPEEGVIRV-RD 488
            ....        ..|.|||...|  ..:.|.:.|.::...|: ::|.......|.:.|...| |.
Mouse   728 KKFQRPQDQYPPFRFGTVPNGST--ERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGARHVSRK 790

  Fly   489 QPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAV-----YGM-VHLNSTYRQLLTQLQV 547
            ...|:|  :|:.:.:...|       .:..:::......|     ||: :..:|.:::.:....:
Mouse   791 LDAFIY--DAAVLNYMAGK-------DEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALL 846

  Fly   548 RMLETGITSKQSRFFSKTKLHTFSNSFV-IQVGMEYAAPLFISLLVAYFLALLILILE--ICW 607
            :.|..|.|.|....:.....|...|..: .::.::..|.:|..||||..||||:...|  :.|
Mouse   847 QFLGDGETQKLETVWLSGICHNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYW 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	43/264 (16%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	62/345 (18%)
		NMDAR2_C	905..>980	CDD:371139	1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846360
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830