DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and Grik2

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	765	Identity:	146/765 - (19%)
Similarity:	254/765 - (33%)	Gaps:	261/765 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYLDSDLVRLGVFLDLGCDKAELVTNQSSRAR 95
            |:|.||::.:.:.                   ||:        .|..|...:.|..:..|:....
Mouse   209 KDAKPLLKEMKRG-------------------KEF--------HVIFDCSHEMAAGILKQALAMG 246

  Fly    96 LYNQNLHWLLYDEAGNFTKLTQL--------FEGANLS----LNADVTYVSREDE----ERF--- 141
            :..:..|::       ||.|...        :.|.|::    ||.:.|.||...|    ||.
Mouse   247 MMTEYYHYI-------FTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304

  Fly   142 -----------------ILHDVYNKGSHLGGKLNITVDQ-------TLQCNRSH-----CQVKEY 177
                             :::|..    |:   :::.|.|       :|||||..     .:....
Mouse   305 PKPDSGLLDGFMTTDAALMYDAV----HV---VSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSL 362

  Fly   178 LSELH---LRPR--------LQHRMDLSSVTFRLAALVSV-----------------LPINSS-- 212
            :.|.|   |..|        |:...||..::.:...|..:                 .|.|.:
Mouse   363 IKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDS 427

  Fly   213 ------------EEELLEFLNSDRDSHMDSISRIGN--------RLIMHTQEILGF--KLHYIWC 255
                        ||..:.|..||:..:       ||        .|:.....||||  ::..:..
Mouse   428 LSNRSLIVTTILEEPYVLFKKSDKPLY-------GNDRFEGYCIDLLRELSTILGFTYEIRLVED 485

  Fly   256 GTWSVQD----AFGGAIGMLTNESAELCTTPFVPSWNR---LHYLHP-MTEQAQFRAVCMFRTPH 312
            |.:..||    .:.|.:..|.:..|:|...|...::.|   :.:..| ||    .....::|.|:
Mouse   486 GKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMT----LGISILYRKPN 546

  Fly   313 NAGIKAAVFLEPFMPSVWFAFAGLLIFAGV--LLWMIFHLER------------HWMQRCL--DF 361
            ........||.|..|.:|...  ||.:.||  :|::|....:            |..||||  ..
Mouse   547 GTNPGVFSFLNPLSPDIWMYI--LLAYLGVSCVLFVIARQSKFSWFKYPNCSHYHHSQRCLCTQH 609

  Fly   362 IPSLLSSCLIS----------------------------FGAACI--QGSYLMPKSAGGRLA--- 393
            :.|.:..||.|                            ||...:  |||.||||:...|:.
Mouse   610 LESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGI 674

  Fly   394 ---FIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLA-DSSLDVGFDTVPFTKTYLVSSP 454
               |..::::|      ||:.:.:.|....:.|.|.:...|| .:.::.|......|.|:...|.
Mouse   675 WWFFTLIIISS------YTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSK 733

  Fly   455 RPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNE 519
            ......::  ...|.|..:.:..|.|||:.|       |.||:.:|:.......::.:...:|.:
Mouse   734 ISTYDKMW--AFMSSRRQSVLVKSNEEGIQR-------VLTSDYAFLMESTTIEFVTQRNCNLTQ 789

  Fly   520 IILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSKQSRFFSKTKLHTFSNSF--------- 574
            |....:|..||: ..:.|.||..:|...:::.|.|            |||.....:
Mouse   790 IGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEG------------KLHMMKEKWWRGNGCPEE 842

  Fly   575 ----VIQVGMEYAAPLFISLLVAYFLALLILILEICW-----ARYAKKKF 615
                ...:|::....:||.|.....|::.:.:.|..:     |:..|:.|
Mouse   843 ESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSF 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	60/278 (22%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	41/245 (17%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	94/444 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840